Abstract 19647: Obesity is Associated With an Exaggerated Postprandial Pro-atherosclerotic Response to High-energy Food in Children
Introduction: Obesity and unhealthy eating are known cardiovascular disease risk factors but their impact in childhood remains unclear. Evidence in adults suggests that metabolic handling of fat and carbohydrate varies in the obese, promoting disease. Little is known about the multi-system response to such food in adults or children. We studied this in teenagers with varying adiposity.
Methods: Twenty healthy volunteers (aged 13-19yrs) ingested 300ml of double (heavy) cream mixed with 89g of maltose syrup (energy 1,635 kcal). Blood pressure (BP) and venous bloods were assessed prior to the meal and for up to 4 hours after the meal. BMI was normalized using WHO reference standards. The continuous interaction between BMI and each meal response measure was assessed in time series regression models.
Results: The figure shows the marginal mean estimates over time for three representative BMI z-scores. High BMI was associated with greater meal responses for systolic BP, VLDL and lymphocyte count (*P<0.001). Differences at rest were not significant. Diastolic BP did not differ. At rest, 1 SD BMI was associated with 0.5 (SE 0.2, P 0.03) higher neutrophil count and 20 (SE 6, P 0.009) higher platelet count but meal responses did not differ. Triglyceride response was associated with BMI in a similar way to VLDL but cholesterol, LDL and HDL did not differ. Haemoglobin and haematocrit did not differ.
Conclusions: We showed a combined haemodynamic, metabolic and inflammatory response in obese children that is likely to be detrimental to their vascular endothelial health. Higher platelet and neutrophil counts may worsen this pro-atherosclerotic state. This evidence supports the hypothesis that cardiovascular risk processes begin early in life. Better understanding of these processes and discovery of appropriate interventions are needed for effective prevention of cardiovascular disease.
Author Disclosures: J. Hauser: None. A. Taylor: None. A. Jones: None.
- © 2015 by American Heart Association, Inc.