Abstract 19301: Blood Pressure Trajectories From Age 7 To 31 are Associated With Augmentation Index at Age 31 in Young Adults: The Kangwha Study
Introduction: Longterm blood pressure (BP) trajectories have been associated with subsequent subclinical atherosclerosis in early adulthood. However the association of BP trajectories at earlier age with subsequent arterial stiffness have not been studied.
Objectives: Are BP trajectories from early childhood to adulthood associated with augmentation index (AIx) in young adults?
Methods: The Kangwha Study is a community-based prospective cohort study that started in 1986 in Kangwha County, South Korea. Study participants were recruited at age 7 years, and 15 follow-up examinations have been conducted until age 31 (every year from age 7 to 18, and at age 20, 26, and 31 years). The current analysis includes 239 (male 110, female 129) participants whose BP were measured at least 3 times (on average 10 times) over 25 years. Augmentation index (AIx) as a measure of arterial stiffness was determined using radial artery tonometry by (Second peak systolic BP- diastolic BP) / (first peak SBP- DBP)*100 at the age 31 examination and adjusted for heart rate 75 were used. Latent mixture modeling was used to identify trajectories in mid-BP ((SBP+DBP)/2) over time. The associations of BP trajectories with AIx were assessed by linear regression.
Results: We identified 5 mid-BP trajectories: low-stable (Group 1; 18.9%), continuously increasing (Group 2; 27.3%), increased slow and remain lower (Group 3; 29.9%), increasing moderately and remain lower (Group 4; 18.6%), and increasing fast and remain (Group 5; 5.3%). When we adjusted for sex and age, group 2 (β=6.05, p=0.01) and group 4 (β=6.72, p<0.01) showed higher AIx than group 1. With additional adjustment for obesity, high fasting glucose, high cholesterol, cigarette smoking, alcoholic drinks, and exercise, group 2 (β=6.53, p=0.01), and group 4 (β=7.47, p<0.01) showed higher AIx than group1.
Conclusions: Longterm BP trajectories from early childhood had increased associations with arterial stiffness in early adulthood.
Author Disclosures: J. Lee: None. N.B. Allen: None. Y. Yano: None. H. Kim: None. J. Lee: None. P. Greenland: None. I. Suh: None.
- © 2015 by American Heart Association, Inc.