Abstract 18867: Multiple Pregnancy Factors and Serum Lipids at Age 40 Year in Swedish Women From the Vasterbotten Intervention Programme
Introduction: Pregnancy factors provide an early window into future cardiovascular disease (CVD) risk in women. It is uncertain which factors, when considered together, independently relate to later lipid levels.
Methods: We used Swedish National Medical Birth Register data linked with the Vasterbotten Intervention Programme cohort. We related pregnancy factors (in any pregnancy) with serum lipid levels at age 40 years in parous women. Using linear regression analysis in crude and multivariable adjusted models, we related total parity, age at first delivery, infertility ≥ 5 years, preeclampsia, small for gestational age (SGA), preterm delivery, placental abruption and gestational diabetes to each of the four clinical lipid variables (total cholesterol, triglycerides HDL-C and LDL-C). HDL-C and LDL-C were measured in a smaller subset of women. Multivariable models were adjusted for all pregnancy factors in addition to annual income, education, smoking status, alcohol intake and body mass index.
Results: In multivariable models, lower parity and younger age at first birth were related to increased total cholesterol (Table). Lower parity, younger age at first birth, gestational age < 37 weeks, and infertility ≥ 5 years were related to increased triglycerides. Preeclampsia was related to increased triglyceride and lower HDL-C only in crude models. Gestational diabetes was related to total cholesterol, triglyceride and lower HDL cholesterol in crude models only. SGA was related to total cholesterol and triglycerides in crude models only. Placental abruption was not associated with any lipid measures in either crude or multivariable models.
Conclusions: Lower parity, younger age at first birth, a history of prolonged infertility prior to pregnancy and preterm delivery are independently related to alterations in lipid levels at age 40 years in women. The association between preeclampsia and later CVD does not appear to be independently mediated by dyslipidemia.
Author Disclosures: N. Parikh: None. M. Norberg: None. E. Ingelsson: None. S. Cnattingius: None. V. Ramachandran: None. M. Domellöf: None. A. Edstedt Bonamy: None.
- © 2015 by American Heart Association, Inc.