Abstract 18828: Association Between Serum Uric Acid Level and Metabolic Syndrome in a Rural Japanese Population
Objective: Several reports have showed associations between serum uric acid (UA) levels and metabolic syndrome (MetS). Limited information, however, is available concerning the prospective relation between UA and the risk of developing MetS. Hypothesis: The aim of this study was to evaluate whether hyperuricemia or their combination predicts MetS.
Methods: We evaluated 1468 subjects (783 male subjects, 685 female subjects; mean age 48.3 years) who underwent health examination programs in 2008 and 2013, who were free of MetS.
Results: At baseline, hyperuricemia was detected in 86 male subjects (11%) and 14 female subjects (2%). Male subjects with baseline hyperuricemia had significantly higher MetS prevalence in 2013 than those without (male subjects: 17.9 vs. 8.4%, P<0.0001; female subjects: 6.1 vs. 1.8%, P=0.143). Compared with subjects in the first quintile of uric acid levels at baseline, the age-adjusted odds ratios (ORs) for MetS cumulative incidence among subjects in the second, third, and fourth quintiles were, 1.2 (95% confidence interval (CI): 0.4-2.8: P=0.07), 2.1 (95% CI: 0.9-4.7: P=0.81) and 1.2 (95% CI: 0.3-4.8: P=0.81), for male subjects. Multivariable logistic analysis revealed that hyperuricemia was significantly associated with MetS cumulative incidence in male subjects (OR 1.9: 95% CI: 1.1-3.1, P=0.013) and not in female (OR 3.8: 95% CI: 0.2-18, P=0.1).
Conclusion: Hyperuricemia is a significant predictor of MetS in rural Japanese male subjects.
Author Disclosures: Y. Nakao: None. S. Mikami: None. H. Takemoto: None. H. Susawa: None. K. Kobayashi: None. H. Tanaka: None. K. Tanaka: None. Y. Kihara: None.
- © 2015 by American Heart Association, Inc.