Abstract 18551: Predisposing Factors of Persistent Symptoms of Depression and Anxiety Among Patients With Acute Coronary Syndrome
Introduction: Depression and anxiety are highly prevalent in patients with acute coronary syndrome (ACS) contributing to poor health outcomes such as mortality and rehospitalization Several studies have also demonstrated a relationship between depression and anxiety and cardiac events in patients with ACS. However, substantial morbidities arise from those patients who persistently suffer from these disorders.
Objective: The primary objective of this study was to determine the predisposing factors of persistent symptoms of depression and anxiety among patients with ACS.
Methods: A total of 1199 patients participated from five hospitals in Dublin, Ireland. Logistic regression analyses were used to determine the predisposing factors of persistent symptoms of depression and anxiety. Predisposing factors included age, gender, body mass index, education level, marital status, smoking history, and diabetes history, history of coronary bypass graft (CABG), stroke, or ACS, baseline knowledge, attitudes and beliefs. We also controlled for baseline anxiety when investigating persistent depression and for baseline depression when investigating persistent anxiety. Patients who been depressed or anxious at baseline and three months follow-up were considered to have persistent depression or anxiety.
Results: Older age (β 0.98; 95% CI: 0.96 - 1.00; p = 0.040), female gender (β 1.99; 95% CI: 1.30 - 3.05; p = 0.002), history of CABG (β 2.10; 95% CI: 1.18 - 3.71; p = 0.011), history of non ST elevation myocardial infarction compared to other ACS (β 1.78; 95% CI: 1.04 - 3.06; p = 0.037), and baseline anxiety (β 1.40; 95% CI: 1.25 - 1.57; p <0.001) were significant predictors of persistent depression. Furthermore, older age (β 0.98; 95% CI: 0.96 - 1.00; p = 0.030), female gender (β 1.98; 95% CI: 1.22 - 3.20; p = 0.005), and baseline depression (β 1.24; 95% CI: 1.14 - 1.36; p <0.001) were significant predictors of persistent anxiety.
Conclusions: Health care providers need to take in consideration the predisposing factors of persistent depression and anxiety to pre-intervene and prevent morbidities associated with these disorders.
Author Disclosures: A. Alhurani: None. T. Lennie: Research Grant; Significant; NIH NINR. D. Moser: None.
- © 2015 by American Heart Association, Inc.