Abstract 18373: Electrocardiographic Intrinsicoid Deflection and Incident Congestive Heart Failure: The Multi-ethnic Study of Atherosclerosis (MESA)
Introduction: Intrinsicoid deflection (ID), the time to R wave peak on the electrocardiogram, represents delayed ventricular activation which possibly denotes impaired myocardial function. We hypothesized that delayed ID is predictive of future heart failure events.
Methods: A total of 6,394 (mean age 62 ± 10; 54% women; 38% whites; 28% blacks; 22% Hispanics; 12% Chinese-Americans) participants without clinically apparent cardiovascular disease or major ventricular conduction delay (QRS ≥120 ms) from the Multi-Ethnic Study of Atherosclerosis (MESA) were included. ID was automatically measured from baseline electrocardiograms (2000-2002) as the maximum ID time in leads V5 and V6. Cox proportional hazards regression was used to compute hazard ratios (HR) and 95% confidence intervals (95%CI) for the association between ID and heart failure.
Results: Over a median follow-up of 11.2 years, a total of 217 (3.4%) participants developed heart failure (incidence rate per 1000 person-years=3.33, 95%CI=2.91, 3.80). In a multivariable Cox regression analysis adjusted for demographics, cardiovascular risk factors, and potential confounders, each 10 ms increase in maximum ID was associated with an increased risk for heart failure (HR=1.42, 95%CI=1.15, 1.74). The results remained similar when stratified by age, sex, and race/ethnicity.
Conclusions: Delayed ID is able to identify individuals at risk for developing heart failure before major conduction delays (e.g., bundle branch block) are evident.
Author Disclosures: W.T. O'Neal: None. W.T. Qureshi: None. S. Nazarian: Other Research Support; Modest; Dr. Nazarian is a consultant and principal investigator for research funding awarded to Johns Hopkins University from Biosence Webster Inc.. N. Kawel-Boehm: None. D.A. Bluemke: None. J.A. Lima: None. E.Z. Soliman: None.
- © 2015 by American Heart Association, Inc.