Abstract 17956: Stratification of Cardiac Electrophysiologic Phenotypes via Systematic Auditory Electrophysiology Evaluation
It is well appreciated that overlap exists between cardiac and auditory electrophysiology, notably the classic example of Jervell Lange Neilson syndrome. We aimed to investigate if further insights into cardiac electrophysiology could be derived via auditory electrophysiology evaluation. We performed a retrospective chart review in the Partners Healthcare system from January 2001- May 2015 for patients who underwent at least 23 hours of a Holter recording as well as an auditory hearing evaluation. 55 patients were identified. Indications for auditory evaluation included patient complaint of hearing loss, symptomatic tinnitus and pre-neurosurgical evaluation. Indications for Holter recordings included complaint of palpitations and heart rate monitoring. Of the 55 patients, 26 (47%) had at least mild sensorineural defect in at least one ear while 28 (51%) had at least mild conductive defect in at least one ear. All auditory evaluations were interpreted by a clinical audiologist. Patients with sensorineural hearing defects had an increased percentage of total (summed atrial and ventricular) ectopic beats when compared to those without any hearing defects as well as those with conductive hearing defects (3.7% versus 0.3% versus 0.5% respectively, p<0.05). The 9 patients (16%) with bilateral sensorineural loss had significant increase in atrial ectopy as a percent of total beats when compared to the 46 patients without bilateral sensorineural hearing loss (6.1% versus 1.1%, p<0.05). Patients with bilateral sensorineural hearing defects had an increased prevalence of atrial fibrillation when compared to those without sensorineural hearing loss (44% vs 14%). In conclusion, a retrospective analysis of a small population of patients having undergone clinical auditory evaluation and Holter monitoring suggests that patients with bilateral sensorineural defects have increased atrial arrhythmias over controls. This finding serves as a hypothesis generating observation regarding the ability of non-cardiac electrophysiologic findings to characterize arrhythmic propensity. These observations further suggest that extracardiac electrophysiologic determinants exist that may be leveraged to better stratify arrhythmic risk.
Author Disclosures: S. Kapur: None. C.A. MacRae: None.
- © 2015 by American Heart Association, Inc.