Abstract 17436: Ten-year Clinical Outcomes After the First Sirolimus-eluting Stent Implantation: Impact of In-stent Restenosis Lesion
Background: Little is known about the clinical follow-up after sirolimus-eluting stent (SES) implantation and about the effect of SES implantation in in-stent restenosis (ISR) lesion more than five years. We aimed to compare clinical outcomes up to 10 years after SES implantation in de novo lesion and ISR lesion.
Methods: A series of 392 patients underwent the first SES implantation between November 2002 and December 2004, whose clinical outcomes were investigated. There were 253 patients for de novo lesion and 139 patients for ISR lesion. We evaluated the outcomes from the SES implantation to five years and beyond five years. Clinical information was obtained either from a review of the hospital records or by telephone interviews with the patients, family members, or primary care physicians.
Results: Mean follow up period was 10.0 years. Cumulative incidence of major cardiac events (MACE) and target-lesion revascularization in ISR group were significantly higher than that in de novo group through 10 years (56.1% vs. 38.7%; p = 0.01, and 41.3% vs. 20.6%; p = 0.004, respectively) and the difference of the MACE and TLR rate in two groups increased in this period. Cumulative incidence of myocardial infarction (MI) and stent thrombosis (ST) between 2 groups were not significantly different (13.0% vs. 7.9%; p = 0.1, and 5.0% vs. 2.4%; p = 0.15, respectively).
Conclusion: The incidence of MACE and TLR after the SES implantation in ISR lesion was significantly higher than that in de novo lesion and the difference of the TLR rate between in two lesions became more clear through 10 years, although the incidence of MI and ST had no significant difference in 2 groups.
Author Disclosures: K. Miura: None. K. Kadota: None. M. Ohya: None. T. Shimada: None. H. Amano: None. Y. Izawa: None. Y. Hyodo: None. S. Otsuru: None. D. Hasegawa: None. S. Habara: None. T. Tada: None. H. Tanaka: None. Y. Fuku: None. T. Goto: None. K. Mitsudo: None.
- © 2015 by American Heart Association, Inc.