Abstract 16904: Are All Omega-3s Created Equal? Comparison of the Bioavailability and Efficacy of Four Omega-3 Preparations
There are many omega-3 products available in the prescription and non-prescription marketplace. Neither health care professionals nor consumers may be aware of the potential influence of the manufacturing processes and source(s) of the starting material. Manufacturers of the various omega-3 preparations imply that their product is superior to others, based on its structural characteristics, whether phospholipid, triglyceride or ethyl ester.
The objective of this study was to compare the ability of four (4) different omega-3 preparations to raise whole blood fatty acid levels. This was a Prospective, Open-label, Blinded Endpoint (PROBE), four period, cross-over study. Thirty-five (35) healthy subjects were randomized to consume one of four test articles for four weeks, followed by a four-week washout, and this process was repeated until all products had been consumed by all subjects. The test article doses were based on their label specifications. The four products and daily doses were:
Triglyceride fish oil:
EPA of 650 mg, DHA of 450 mg
Ethyl Ester fish oil:
EPA of 756 mg, DHA of 228 mg
Phospholipid krill oil:
EPA of 150 mg, DHA of 90 mg
Triglyceride salmon oil:
EPA of 180 mg, DHA of 220 mg
Blood samples before and after supplementation were quantified for whole blood fatty acids by gas chromatography flame ionization. Bioavailability was assessed for each product individually, based on its change from baseline. Percentage change from baseline was then compared across all four products.
TG fish oil was statistically superior to all of its comparators in the bioavailability of EPA+DHA, and of DHA alone. Its EPA percentage increase was more than four times that of PL krill oil and TG salmon oil. Only the two TG products significantly increased whole blood
DHA levels. For investigators and clinicians, the type and dose of omega-3s may be clinically important when assessing potential clinical impact.
Author Disclosures: R.W. Butt: None. C.A. Cockerline: None. W.J. Rowe: None. M. Laidlaw: None.
- © 2015 by American Heart Association, Inc.