Abstract 16341: Trends of Inpatient Burden of Primary Pulmonary Hypertension in USA: Analysis of Nationwide Inpatient Sample Database From 2001-2012
Background: Primary pulmonary hypertension (PPH) is a rare pulmonary vascular disease characterized by endothelial dysfunction and vascular remodeling of small pulmonary arteries, resulting in elevated pulmonary artery pressures. The cause of endothelial dysfunction is usually unknown. PPH is a progressive disease resulting in reduced cardiac output, right heart failure, and death. We aimed to evaluate the characteristics of hospitalizations for PPH in United States.
Methods: We analyzed the National Inpatient Sample Database (NIS) for all subjects in which PPH (ICD code 416.0) was the principal discharge diagnosis from 2001-2012. Data is presented as mean ± SE.
Results: In 2001, there were 3177 admissions with a principal discharge diagnosis of PPH as compared to 1345 in 2012 (p<0.001) (Figure). Rate of discharge per 100,000 persons decreased significantly from 1.1 ± 0.1 to 0.4± 0.0 (p<0.001). However, the mean length of stay (7.03±0.5 in 2001 vs 7.6±0.6 in 2001, p= 0.5) and in-patient mortality (7.75±1.07 % in 2001 vs 6.32±1.68 % in 2001, p= 0.47) has not changed significantly between 2001 and 2012. It is important to note that during this period the mean hospital charges increased by 269.8 % from $29507 per patient in 2001 to $79607 per patient in 2012 (p<0.0001).
In 2012, 68% of patients were between ages 45-84 years and 72.9% were females. Medicare was billed for about half the hospital stays in 2012 (49.4%). The routine discharges constituted about 62.45% of total discharges, followed by home health care (18.6%) and nursing home/ rehab (6.7%).
Conclusion: The number of inpatient admissions and rate of discharge for primary pulmonary hypertension has decreased significantly over the last 13 years. The cost associated with these admissions has however increased substantially, even though there is no significant change in the duration of inpatient stay and inpatient mortality rates.
Author Disclosures: V. Anand: None. T. Thenappan: None.
- © 2015 by American Heart Association, Inc.