Abstract 16188: Is Hypertrophic Cardiomyopathy Associated With Aortopathy: An Imaging and Epidemiologic Case Control Study
Introduction: A single prior case series has raised the concern that hypertrophic cardiomyopathy (HCM) and dilated aorta (DA) may be associated due to congenital or acquired reasons. This hypothesis has never been formally tested in prior research studies.
Hypothesis: To evaluate the prevalence of DA in patients with HCM.
Methods: We queried echocardiography database and electronic medical record system of our large tertiary care center for DA and HCM, respectively, over the last 4 years, in adults >15 years of age DA was defined as a sinus of Valsalva dilation (SVD), HCM was defined based on the presence of ICD 9 codes presence and cause- effect analysis was carried out with stratified analysis, followed by multivariate logistic regression analysis.
Results: We found 553 patients with hypertrophic cardiomyopathy. In the echocardiography database, (SVD) measurement was available on 37,914 patients with 1035 patients with DA. The prevalence of DA was more than twice in those with HCM as compared to those without HCM (odds ratio 2.35; 95% confidence interval 1.33, 3.84; p value 0.001). This association persisted in stratified analyses for 28 causes of aortopathy, without meaningful confounding. This association persisted in a multivariate logistic regression model which included age, sex, diabetes, hypertension, dyslipidemia, smoking and aortic valve disease (odds ratio 1.87; 95% confidence interval 1.01, 3.14; p value 0.02). This association was higher in strength to that between aortic valve disease and DA (OR 2.35 vs.2.03).
Conclusions: Our data support the hypothesis that HCM is associated with DA. The strength of association approaches other established causes of DA.
Author Disclosures: K. Ammar: None. M. Ahmad: None. M. Ahmad: None. R. Yousefzai: None. J. Krishnaswamy: None. B. Khandheria: None. R. Jain: None. A. Tajik: None.
- © 2015 by American Heart Association, Inc.