Abstract 16122: Is Vitamin D Deficiency Really Associated With an Increased Incidence of Statin Intolerance?
Introduction: Statin therapy is potentially the most important treatment presently available to prevent the progression of atherosclerosis. Unfortunately, a significant number of patients cannot tolerate statins due to muscle aches. Vitamin D deficiency, which is also associated with a variety of muscular symptoms, is commonly identified among patients with an indication for statin therapy. Several small studies have proposed that vitamin D deficiency may contribute to statin intolerance, but this has not been definitively demonstrated.
Hypothesis: Vitamin D deficiency is associated with greater risk of statin intolerance.
Methods: In the Intermountain Healthcare electronic health record, 12,066 patients had an initial 25(OH) vitamin D (VitD) level available and an indication for statin therapy with either a documented statin intolerance or evidence of active statin therapy. Patient baseline clinical characteristics were collected and multivariable logistic regression analysis was used to evaluate associations between VitD levels (stratified into four categories (ng/ml): <12 [n=660(5.5%)], 12 to <20 [2,057(17.0%)], 20 to <50 [8,183(67.8%)], ≥50 [n=1,166(9.7%)]) and statin intolerance.
Results: Overall, 12,066 subjects (statin intolerant n=928 [7.7%]; age = 56±6 yrs; males = 37.5%, prior atherosclerotic cardiovascular disease = 1856 [15.4%]) were enrolled. Multivariable effects of VitD and other predictors on risk of statin intolerance are shown in the Table.
Conclusion: In this large cohort of patients with an indication for statin therapy, baseline VitD levels were not significantly associated with statin intolerance. Characteristics that were associated with statin intolerance included older age, female gender, Caucasian race, diabetes and a prior diagnosis of hyperlipidemia.
Author Disclosures: T.L. Bair: None. S. Knight: None. H.T. May: None. B.D. Horne: None. J.L. Anderson: None. D.L. Lappé: None. J.B. Muhlestein: None.
- © 2015 by American Heart Association, Inc.