Abstract 15896: Higher Baseline Body Mass Index Predicts Longitudinal Increase in C-Reactive Protein but not Vice Versa
Introduction: Basic research shows that adipose tissue is proinflammatory, and inflammation in turn may cause adipose tissue accumulation through insulin resistance. However, it is not well understood whether adiposity or inflammation, or equally both, are drivers of this vicious cycle. We examined this question through longitudinal structural equation modeling (SEM).
Methods: We analyzed data from 869 GeneSTAR Study participants from 374 families who were free of clinical cardiovascular disease throughout the follow-up period, and had two study visits 2 to 8 years apart. Body Mass Index (BMI) was used as a measure of adiposity, and log transformed high sensitivity C-Reactive Protein (CRP) as a measure of inflammatory state. The crossed lag SEM for correlations is presented in the Figure, adjusting for demographic factors and smoking during the two visits. The predictive associations of follow-up BMI and CRP with baseline CRP and BMI, respectively, are adjusted for cross sectional correlations and longitudinal inertia of variables. We also estimated the beta coefficients of the crossed lag associations using generalized SEM, accounting for non-independence of families.
Results: Baseline BMI was associated with follow-up CRP (3.6% increase/BMI unit, p<0.001), but baseline CRP was not associated with follow-up BMI (p = 0.66). The crossed lag correlations were significantly different (p < 0.001).
Conclusions: Higher adiposity is the driver of its vicious cycle with inflammation. For future studies, we conjecture that weight control is likely to be more effective as compared to treatment of inflammation in improving the coupled metabolic and inflammatory profile over time.
Author Disclosures: D. Vaidya: Research Grant; Significant; National Institutes of Health. Consultant/Advisory Board; Significant; Consumable Science, Inc. L.R. Yanek: None. B.G. Kral: None. R.A. Mathias: Research Grant; Significant; National Institutes of Health. L.C. Becker: Research Grant; Significant; National Institutes of Health. D.M. Becker: Research Grant; Significant; National Institutes of Health.
- © 2015 by American Heart Association, Inc.