Abstract 15583: Serum Vitamin D Deficiency is Independently Associated With Greater Prevalence of Erectile Dysfunction: Results From the National Health and Nutrition Examination Survey (NHANES) 2001-2004
Background: Erectile dysfunction (ED) and cardiovascular disease (CVD) share common risk factors. Furthermore, up to 80% of ED is from vascular causes, and thus ED may be a marker for subclinical CVD. Low serum 25-hydroxyvitamin D [25(OH)D] levels have been associated with increased CVD risk, perhaps mediated through hypertension and diabetes, but it is unclear if low serum 25(OH)D is associated with ED, independent of CVD risk factors.
Methods: We performed a cross-sectional analysis of 3,486 men aged ≥20 years free of CVD who participated in NHANES 2001-2004. Serum 25(OH)D was measured by the DiaSorin radioimmunoassay. We defined vitamin D deficiency as a serum level of 25(OH)D <20 ng/mL. Self-reported erectile function was assessed by a single question: “How would you describe your ability to get and keep an erection adequate for satisfactory intercourse?” We defined ED as those who answered “sometimes able” or “never able.” We assessed the relationship between serum 25(OH)D deficiency and prevalence of ED using logistic regression after adjusting for potential confounders.
Results: The prevalence of vitamin D deficiency and of ED was 30% and 16.4%, respectively. Serum 25(OH)D levels were statistically significantly lower in men with vs those without ED (mean 22.9 vs 24.3 ng/mL, respectively; p=0.0007). Vitamin D deficient men had a significantly higher prevalence of ED compared to those without deficiency (age- and race-adjusted OR 1.53, 95% CI 1.17-2.00). This association was materially unchanged after adjusting for multiple lifestyle variables, comorbidities, and medication use (OR 1.32, 95% CI 1.02-1.74) [Figure].
Conclusion: In this cross-sectional analysis of a representative sample of U.S. men, vitamin D deficiency was associated with an increased prevalence of ED independent of CVD risk factors. Additional research is needed to evaluate if treating vitamin D deficiency results in an improvement of erectile function or prevents vascular events.
Author Disclosures: Y.M. Farag: None. E. Guallar: None. D. Zhao: None. R.R. Kalyani: None. S.S. Martin: None. P.L. Lutsey: None. K.L. Billups: None. E.D. Michos: None.
- © 2015 by American Heart Association, Inc.