Abstract 15403: Is the Sum Greater Than the Whole? Association of Heart Risk Factors and Echocardiographic Parameters With Reduction in 6-Minute Walk Test in Stage A Heart Failure
Introduction: Chemotherapy increases long-term risk of heart failure (HF), but its impact relative to other HF risk factors is unknown. 6 minute walk test (6MWT) provides prognostic information regarding hospitalization and mortality in HF patients. We sought the relative role of these factors on echocardiographic changes and 6MWT.
Hypothesis: Prior chemotherapy is associated with greater functional impairment than other stage A HF risk factors.
Methods: We recruited 521 asymptomatic pts from the community aged ¬>65 years with stage A heart failure (SAHF, based on at least one of: diabetes, obesity, hypertension, coronary artery disease or chemotherapy). All went echocardiographic studies and 6MWT. 45 patients had previous chemotherapy (mean interval 7±7.5 years) and underwent 6MWT. These patients were matched 2:1 using demographic and clinical characteristics with patients who did not receive chemotherapy. Fisher’s test and independent t-test were used for statistical analysis.
Results: There were no significant difference in demographic variables. The chemotherapy group had a significantly lower 6MWT distance (mean difference -155m) and significantly higher proportion of patients with 6MWT distance < 400m (26.7% vs. 11%, p=0.043). There were no significant difference in other echocardiographic parameters assessing systolic, diastolic and geometrical parameters.
Conclusion: Prior chemotherapy has a significant long-term effect on functional capacity in comparison with other SAHF factors. As no one echo parameter was associated with this difference, this could potentially be secondary to noncardiac (including vascular) parameters.
Author Disclosures: M.T. Nolan: None. Y. Wang: None. H. Yang: None. T.H. Marwick: None.
- © 2015 by American Heart Association, Inc.