Abstract 15350: Dietary Omega-3 Fatty Acids and Fiber Intake Increase Adiponectin Levels in African American Adults With Metabolic Syndrome
Introduction and Purpose: Adiponectin is a key peptide involved in the relationship between adiposity, insulin resistance and inflammation. Lower plasma levels are associated with metabolic syndrome (MetS), type 2 diabetes mellitus, and coronary artery disease. African Americans (AA) have lower levels of adiponectin compared to other racial/ethnic groups. While clinical trials have examined the effects of dietary intake of omega-3 fatty acids, fiber, and other nutrients on adiponectin levels and metabolic risk, few studies have examined these relationships in AA adults. The purpose of this study is to examine the relationship between dietary factors and adiponectin in AA adults with MetS.
Methods: This analysis is of baseline data from a larger, longitudinal lifestyle intervention study in AA adults with metabolic syndrome. Dietary intake was assessed with the 2005 Block Food Frequency Questionnaire. Plasma adiponectin was measured by ELISA. Analysis included descriptive statistics, correlations and multiple regression.
Results: Seventy-four participants, 50.5±9.1 years of age, 77% female, were included in this analysis. Most participants (N=62, 85%) were obese, with mean BMI 35.6±6.3 and mean waist-hip ratio (W:H) 0.95±.05 for males and 0.88±.08 for females. Mean omega-3 intake was .77±0.5g and fiber intake was 15.47±7.9g. Adiponectin was higher in females than males (7.7±4.0 vs 5.4±3.3, t=-2.8, p=.007) and negatively associated with W:H (r=-.20, p=.03). Adiponectin had a positive linear relationship with omega-3 (R2=.235, p=.003) and fiber (R2=.201, p=.015) intake, controlling for gender and W:H. These relationships are consistent with studies in other ethnic groups.
Conclusion: Higher adiponectin levels are protective with metabolic risk factors, particularly central adiposity. Increased consumption of omega-3 fatty acids and fiber is associated with higher levels of adiponectin and may confer risk protection in AA adults with MetS. Culturally tailored strategies aimed at improved dietary quality, particularly focused on increasing dietary intake of omega-3 fatty acids and fiber are warranted.
Author Disclosures: E.P. Ferranti: None. B. Butts: None. C.M. Reilly: None. S.B. Dunbar: None.
- © 2015 by American Heart Association, Inc.