Abstract 15057: Cardiovascular Outcomes and Stroke Rates in Hospitalized Patients With Cancer and Atrial Fibrillation-A Study Using the 2012 National Inpatient Sample
Background: Patients with cancer (CA) who develop atrial fibrillation (AF) have increased morbidity and mortality. CA is associated with venous thromboembolism (VTE), however its impact on stroke rate is unclear. The efficacy of the CHADS2 score in assessing stroke risk in patients with AF and CA is unknown. This study compares clinical characteristics, cardiovascular outcomes and stroke rate in hospitalized patients with AF and CA versus those with AF without CA.
Methods: Using the 2012 National Inpatient Sample (NIS), we identified admissions in patients >18 years associated with AF. Patients with active CA were then identified. Clinical characteristics and cardiovascular outcomes including stroke rate were collected.
Results: Of the 7,296,968 admissions in the 2012 NIS, 751,009 (10.3%) were associated with AF. Patients with CA represented 10.4% (78,099) of admissions with AF. The most common cancers were lung (18.6%), lymphoma (8.1%), leukemia (8.5%), and prostate (8.0%). Patient characteristics (Table 1) were all significantly different to a p value of <0.001, with the exception of tobacco use.
Patients with AF and CA had fewer cardiovascular events (Table 2) except for VTE. Those with AF and CA also had longer lengths of stay and higher mortality. There were statistically significant differences (p <0.001) in all clinical outcomes.
Conclusion: Atrial fibrillation in patients with cancer is associated with adverse outcomes, including venous thromboembolism, length of stay and mortality but is not associated with increased rate of stroke. In patients with cancer and atrial fibrillation increasing rate of stroke was associated with increasing CHADS2 score.
Author Disclosures: M. Sullivan: None. J. Shatzel: None. S.E. Friedman: None. R.T. Palac: None. A. Gemignani: None.
- © 2015 by American Heart Association, Inc.