Abstract 14799: Clinical Outcomes and Health-related Quality of Life of Catheter Ablation vs. Anti-arrhythmia Drug Therapy Among Atrial Fibrillation Patients in China
Introduction: Although catheter ablation of atrial fibrillation(AF) has been demonstrated to be associated with significantly better rhythm control compared with anti-arrhythmia drug therapy (AAD),whether this treatment can improve Health-Related Quality of Life (HRQOL) remains unknown.
Methods: This is a prospective, single center study conducted in Beijing Anzhen Hospital. Patients were treated at the discretion of their physician and propensity score matching was performed to ensure the comparability of patients in the ablation and AAD arms. HRQOL evaluated at each 3-month follow up period was the primary endpoint of this study. The first 3 month after enrollment was excluded as a blanking period. HRQOL were measured using Short Form-36 (SF-36) and Atrial Fibrillation Effect on Quality-of-life questionnaire (AFEQT).
Results: This study enrolled 318 and 151 subjects in the drug treatment and catheter ablation arms respectively. For the matched 75 pairs of paroxysmal AF subjects, 82.0% in the ablation arm and 22.4% in the AAD arm was in sinus rhythm at 12 month follow up. For the matched 57 pairs of persistent AF, 65.3% and 19.3% patients was in sinus rhythm in the ablation and AAD arms respectively. In the ablation arm, the subjects showed significant improvement in their SF36 and AFEQT scores compared with subjects in the AAD arm (all p<0.001 when compared with AAD subjects at the same follow up period, Figure 1)
Conclusion: The ablation treatment has demonstrated significantly improved quality of life compared with anti-arrhythmia drug therapy in Chinese AF patients.
Table of Contents
Author Disclosures: X. Du: Research Grant; Significant; Project was supported by a grant from Johnson and Johnson, Inc.. J. Wu: None. X. Guo: None. S. Li: None. C. Sang: None. R. Yu: None. D. Long: None. J. Dong: None. Y. Jia: Employment; Significant; Yu Jia is an employee of Johnson and Johnson, Inc.. J. Xuan: None. C. Ma: None.
- © 2015 by American Heart Association, Inc.