Abstract 14601: Vegetarianism is Independently Associated With Lower Risk of Left Ventricular Diastolic Dysfunction and Stage B Heart Failure Burden
Introduction: Heart failure (HF) affects about 6 million Americans at an annual direct cost of $40 billion. Left ventricular (LV) diastolic dysfunction and stage B HF are predictors of clinical HF and reduction of stage B HF burden may help reduce HF disease burden in the community. In our Adventist Health Study-2 (AHS-2) of 96,000 subjects, a vegetarian compared to a non-vegetarian diet was associated with lower body mass index, and risk of diabetes and hypertension despite similar caloric intake.
Hypothesis: We hypothesized that vegetarianism would also lead to a lower risk of LV diastolic dysfunction and stage B HF.
Methods: We invited a random sample of 206 subjects from AHS-2 stratified by diet (vegetarians, lacto-ovo vegetarians, pescovegetarians and nonvegetarians), aged >60 years and living within 50 miles of Loma Linda for a clinic visit consisting of a history, anthropometrics, blood pressure measurement, food frequency questionnaire and a full echocardiogram. LV volume, EF, wall motion, diastolic function and mass and left atrial size were assessed based on guidelines of American society of Echocardiography.
Results: The mean age was 74 (10) years, 49% were males and subjects were equally distributed in 4 food groups. LV diastolic dysfunction was present in 60%, LV hypertrophy in 10%, LVEF <50% in 5% and increased left atrial volume index in 45% of the subjects. After adjusting for age, gender, race, body surface area, prevalent MI, diabetes and hypertension, a vegan diet (no animal products), compared to non-vegetarian diet, was associated with a lower prevalence of LV diastolic dysfunction (OR 0.42, 95% CI 0.24-0.73) and LV hypertrophy (OR 0.30, 95% CI 0.08-0.86) Vegetarians also had a lower number of stage A risk factors and stage B components (p<0.05). There was a trend towards graded increase in risk of stage B HF with increasing degree of nonvegetarianism.
Conclusions: A vegan diet is independently associated with lower risk of LV diastolic dysfunction, LV mass and stage B HF burden.
Author Disclosures: R.G. Pai: None. P. Varadarajan: None. B. Jabo: None. A. Maschak: None. P. Herring: None. G.E. Fraser: None. S.F. Knutsen: None.
- © 2015 by American Heart Association, Inc.