Abstract 13864: Associations Between the Amount and Intensity of Physical Activity and Major Cardiovascular Events in Patients With Stable Coronary Heart Disease: Results From the STABILITY Trial
Introduction: Secondary preventive guidelines recommend patients with stable coronary heart disease (CHD) take at least 30 min of moderate or vigorous physical activity (PA) on at least 5 days/week.
Hypothesis: Lower levels of PA may be beneficial for cardiovascular (CV) prognosis.
Aim: To evaluate associations between self-reported PA, including mild intensity exercise and outcomes in a global cohort of patients with stable CHD.
Methods: A lifestyle questionnaire was completed at baseline by 15,486 (97.8%) STABILITY participants. Total PA was estimated from individual subject self-reports of hours spent each week on mild, moderate and vigorous exercise, 2, 4 and 8 METS respectively. Associations between the total amount of PA and MACE (CV mortality, non-fatal myocardial infarction or non-fatal stroke), CV and non-CV mortality were evaluated using Cox proportional hazard models adjusting for age, gender, treatment allocation, markers of disease severity and CV risk factors during a median follow-up of 3.7 yrs.
Results: For all subjects, a greater proportion of MET.hours was spent taking mild (50.4%) compared to moderate (39.7%) and vigorous (10.0%) PA. The mean (±SD) PA reported for the ‘sedentary’ (t1, n=5281), ‘mildly active’ (t2, n=5055) and ‘moderately active’ (t3, n=5151) tertiles were t1 12.1±7.4, t2 39.6±7.4 and t3 104.3±45.9 MET.hours/week. Compared to ‘sedentary’ subjects the ‘mild’ and ‘moderate’ PA tertiles had a lower risk of MACE HR 0.96 (95% CI 0.85-1.08) and 0.79 (0.70-0.91), p=0.0019, CV death 0.89 (0.75-1.06) and 0.69 (0.57-0.85), p=0.0019, and non-CV death 0.54 (0.41-0.72) and 0.72 (0.55-0.95), p<.0001. See Figure.
Conclusions: In patients with stable CHD there is a strong inverse association between self-reported PA and MACE, CV mortality and non-CV mortality. Even modest amounts of mild intensity exercise are associated with lower mortality.
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- © 2015 by American Heart Association, Inc.