Abstract 13842: Fat Free Mass Index is an Important Predictor for Future Cardiac Events in Patients After Cardiac Surgery
Introduction: Sarcopenia is defined as skeletal muscle loss and dysfunction in aging and chronic disease, and associated with increased occurrence of complication after cardiac surgery. Fat-free mass index (FFMI) is used for the clinical diagnosis of sarcopenia. We previously reported sarcopenia evaluated by FFMI were associated with an unfavorable prognosis in patients with chronic heart failure (CHF). However, the impact of sarcopenia on long term prognosis after cardiac surgery remains to be determined
Method and Resultss: We included 135 patients who underwent cardiac surgery including coronary artery bypass graft and valve replacement in our hospital between 2007 and 2009. We calculated fat free mass (FFM) by using following formula before cardiac surgery: FFM=7.38+0.02908хurinary creatinine (mg/day), and FFM was normalized by square of their height in meter (FFMI). Primary endpoint was major adverse cardiac events (MACE). Secondary endpoint was extended hospital length of stay. There were 3 perioperative deaths and 34 MACEs during the follow-up periods (median 3.8 years). Patients with MACE had significantly lower FFMI than those who without (12.7 vs 14.7 kg/m2, p<0.01). Logistic analysis showed that FFMI was independently associated with extended length of hospital stay [Odds ratio: 0.82, 95% confidence interval (CI) 0.65-0.98, p<0.05]. Multivariate Cox proportional hazard analysis revealed FFMI was independently associated with poor outcomes after adjustment of confounding factors (Hazard ratio: 0.86, 95% CI 0.75-0.98, p<0.05). Kaplan-Meier analysis showed that a higher cardiac event rate was observed in patients with low FFMI compared with those who with high FFMI.
Conclusions: Decreased FFMI was associated with poor outcomes after cardiac surgery.
Author Disclosures: D. Kinoshita: None. T. Watanabe: None. T. Sugai: None. T. Toshima: None. T. Takahashi: None. M. Yokoyama: None. T. Narumi: None. T. Shishido: None. I. Kubota: None.
- © 2015 by American Heart Association, Inc.