Abstract 13830: Senescent CD8+ T Cells Are Increased and Associated With Clinical Outcome in Patients With Heart Failure
Background: The pathogenic role of T cells in heart failure (HF) has been well documented in recent animal studies. However, the existence of T cell driven inflammation in patients with HF has not been confirmed. Therefore, we studied immunologic characterization of T cells from patients with HF.
Methods: We compared the frequency of senescent T cells in 23 end-stage HF patients (11 male, mean age 48 ± 13 years), 23 age- and sex-matched healthy control subjects (11 male, mean age 49 ± 12 years) and 17 newly diagnosed acute HF patients (8 male, mean age 59 ± 18 years) by multicolor flow cytometry. Senescent T cells were defined as CD28null or CD57+ cells in CD4+ or CD8+ T cell subset. Primary endpoint was cardiovascular (CV) events defined as CV mortality and rehospitalization due to HF aggravation.
Results: The frequency of senescent CD8+ T cells was significantly increased in patients with end-stage HF compared to healthy control (CD8+CD57+ T cell fraction: 46.3 ± 22.3% vs. 29.0 ± 13.1%, p=0.003; CD8+CD28null T cell fraction: 47.7 ± 20.2% vs. 27.8 ± 12.1%, p<0.001). Regarding the newly diagnosed acute HF patients, patients with CV events showed significantly higher CD8+CD57+ T cell fraction compared with those with no CV events (46.5 ± 9.2% vs. 29.9 ± 11.5%, p=0.037).
Conclusion: Senescent CD8+ T cells are increased and associated with clinical outcome in patients with HF, suggesting a role for T cell driven inflammation in HF. A more detailed characterization of senescent CD8+ T cells may offer new opportunities for the prevention and treatment of HF.
Author Disclosures: J. Youn: None. H. Yu: None. J. Oh: None. S. Park: None. S. Lee: None. D. Choi: None. E. Shin: None. S. Kang: None.
- © 2015 by American Heart Association, Inc.