Abstract 13650: Influence of Parathyroid Hormone on Incidence of Heart Failure Event in Patients Without History of Cardiovascular Disease
Introduction: Parathyroid hormone (PTH) plays an important role in bone metabolism. High PTH level increases intracellular calcium in arterial wall, which causes hypertension and left ventricular hypertrophy. However, information on the association of PTH level with cardiovascular event in general population is still lacking. In this study, we investigated the association of PTH with biochemical and echocardiographic measurements of cardiovascular structure and function, and the influence of PTH on incidence of heart failure (HF) admission in patients without history of cardiovascular disease.
Methods: 172 subjects (84male, 68years) without history of cardiovascular disease were enrolled from September 2012 to April 2013. Subjects with LV dysfunction (LVEF <50%) and advanced chronic kidney disease (eGFR<15 ml/min/1.73m2) were excluded. Parathyroid function was assessed with intact PTH (iPTH). We examined the association of iPTH with biochemiacl markers, such as NT-proBNP, high-sensitive cardiac Troponin T (hs-cTnT), and echocardiographic markers, such as left atrial volume index (LAVI), left ventricular mass index (LVMI), LVEF, E/e.Associations of iPTH with these cardiac markers were evaluated by univariable and multivariable linear regression analysis. Association of iPTH with future cardiovascular event was also evaluated by using multiple Cox regression analysis.
Results: In multivariable analyysis, log NT-proBNP (p=0.0121) as well as log hs-cTnT (p=0.0024) was associated with iPTH. Among echocardiographic measurements, LAVI (p=0.0161), LVMI (p=0.0343) and E/e (p=0.0001) were associated with iPTH after adjustment for age, gender, cholesterol and eGFR. In multivariate Cox regression analysis, increasing iPTH was associated with incidence of HF admission with a hazard ratio of 6.39 for iPTH over 60 pg/ml (95% CI: 1.003 to 46.111, p=0.0047) after adjustment for age, gender, prevalence of hypertension, diabetes mellitus, dyslipidemia, systolic blood pressure and heart rate.
Conclusions: Parathyroid hormone is associated with greater cardiac markers and future heart failure. Our results suggest that treatment to reduced PTH level is helpful to prevent future cardiac event.
Author Disclosures: S. Sakuragi: None. K. Ichikawa: None.
- © 2015 by American Heart Association, Inc.