Abstract 13565: Patterns of Newly Detected Atrial Fibrillation and Antithrombotic Treatment in GLORIA-AF Phase II
Purpose/Background: Anticoagulation with Vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) is recommended for patients with atrial fibrillation (AF) and additional risk factors for stroke, regardless of the pattern of AF. Using an inception cohort design, GLORIA-AF collected data on antithrombotic therapy choices for patients with newly identified AF at risk of stroke in the course of routine care.
Methods: Phase II began after the first NOAC became available for stroke prevention in AF and baseline data were recorded from November 2011 through December 2014 in 44 countries worldwide. To reduce selection bias, patients were recruited consecutively, irrespective of antithrombotic therapy received. Antithrombotic treatment is presented in relation to CHA2DS2VASc scores and the pattern of AF.
Results: In phase II of GLORIA-AF, 15,092 patients with a recent diagnosis of AF and CHA2DS2VASc scores ≥ 1 were enrolled. Median age was 71 years and 39.1% were ≥ 75 years old; 45.5% were female, 74.6% had a history of hypertension, 23.1% diabetes mellitus and 86.1% had CHA2DS2VASc scores ≥ 2. AF was classified as paroxysmal in 53.4% (n = 8052), persistent in 35.5% (n = 5362) and permanent in 11.1% (n = 1678) of patients. Relationships of initial antithrombotic therapy to AF pattern and stroke risk are shown in the figure below and further data on regional differences will be presented.
Conclusion: Initial antithrombotic therapy diverged from guideline recommendations. Patients with paroxysmal AF were less often anticoagulated than those with persistent or permanent AF, and nearly 22% of patients with paroxysmal AF at high stroke risk were untreated, or given aspirin or other antiplatelet therapy alone.
Author Disclosures: J.L. Halperin: Consultant/Advisory Board; Modest; Janssen, Pfizer. Other; Modest; AstraZeneca. Consultant/Advisory Board; Significant; Boehringer Ingelheim. M.V. Huisman: None. H. Diener: None. S.J. Dubner: None. C. Ma: None. K.J. Rothman: None. N. Schoof: None. A. Elsaesser: None. M. Paquette: None. D.B. Bartels: None. C. Teutsch: None. G.H. Lip: None.
- © 2015 by American Heart Association, Inc.