Abstract 13516: Chronic inflammation, Albuminuria, and Hospital Admissions Among Adults With Hypertension: The National Health and Nutrition Examination Survey 2003-2012
Background: Although clinical factors such as advanced age, co-morbidities, or polypharmacy have been extensively documented as crucial predictors for hospitalizations, data examining the associations of preclinical disease indicators such as albuminuria and subclinical inflammation with hospitalization among people with hypertension are sparse.
Methods: Data were from 5149 adults (>20 years) with hypertension in the National Health and Nutrition and Examination Survey 2003-2012. Overnight hospitalization during the past 12 months (H) was ascertained by questionnaire. C-reactive protein (CRP) was quantified by latex-enhanced nephelometry. Urinary albumin-to-creatinine ratio (UACR) was categorized into normal, microalbuminuria (MiA), and macroalbuminuria (MaA).
Results: Both MiA (UACR 30-300mg/g) and MaA (UACR>300mg/g) were associated with H in patients with hypertension. In the full-adjusted model, odd ratios (ORs) of H were 1.74 (95% confidence interval [CI] 1.25-2.42) and 1.27 (95% CI 1.05-1.54), respectively, comparing participants with MaA and MiA to those without albuminuria. CRP>0.3mg/dL was associated with increased odds of H comparing with normal CRP (OR 1.31; 95%CI 1.06-.162). Subjects with both albuminuria and elevated CRP had higher odds of H than individuals with no albuminuria and normal CRP (Figure).
Conclusion: Albuminuria and inflammation were independent correlates for H among adults with hypertension. There was an interaction of albuminuria and elevated CRP on H, suggesting that the presence of subclinical inflammation may amplify the effect of albuminuria on hospitalization in adults living with hypertension. We provided new information on role of preclinical biomarkers in hospitalization among community-dwelling adults with hypertension where data currently are not available.
Author Disclosures: H. Kuo: None. J.M. Gore: None.
- © 2015 by American Heart Association, Inc.