Abstract 13415: Predictive Value of Glomerular Filtration Rate-Adjusted Contrast Volume for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention
Introduction: Contrast volume (CV) to estimated glomerular filtration rate (eGFR) ratio has been known as a useful predictor of contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI). However, a cutoff value of CV/eGFR has not been established.
Hypothesis: We investigated the clinical predictors and predictive value of CV/eGFR for CI-AKI in patients with coronary artery disease (CAD) underwent PCI.
Methods: This study consists of 479 hemodynamically stable CAD patients (mean age: 73±10 years) underwent PCI. Patients, and target lesion characteristics were obtained. The primary endpoint was the occurrence of CI-AKI defined as an increase in serum creatinine of 0.5 mg/dl or 25 % within 48 hours after contrast injection. Logistic regression analysis was used to estimate the association of clinical risk factors with development of CI-AKI. Receiver-operating characteristic curve (ROC) analysis was performed to determine the predictive value of CV/eGFR for CI-AKI.
Results: Mean procedural CV was 93±38 ml. CI-AKI was occurred in 19 patients (3.9%). Multivariate logistic regression analysis showed that higher CV/eGFR (odds ratio; 1.8, 95% confidence interval; 1.03-2.98; p=0.03) was a statistically significant predictor of CI-AKI independent other risk factors (Table). Using ROC analysis for prediction of CI-AKI, the area under the curve was 0.67, and the best cutoff value of CV/eGFR was 1.64 (sensitivity was 8.0%, specificity was 98%, positive and negative predictive values were 58% and 73%, respectively).
Conclusions: The results of this study suggest that high CV/eGFR is a predictive marker for CI-AKI after PCI independent of other clinical risk factors. Reducing a CV less than 1.64 of eGFR might be valuable in preventing CI-AKI after PCI.
Author Disclosures: H. Nakamura: None. K. Otsuka: None. T. Yamaguchi: None. H. Ishikawa: None. H. Katayama: None. H. Takeda: None. K. Fujimoto: None. M. Yoshiyama: None. N. Kasayuki: None.
- © 2015 by American Heart Association, Inc.