Abstract 13131: Impact of Exercise Training on Cardiac Structure and Function in Patients With Type-2 Diabetes or Obesity: A Meta-analysis of Randomized Control Trials
Background: Type 2 Diabetes mellitus (T2DM) and obesity are associated with subclinical abnormalities in left ventricular structure and function and an increased downstream risk for heart failure. Exercise training has been associated with significant improvement in cardiorespiratory fitness among these patients. However, its impact of cardiac structure and function is not well established. In this meta-analysis, we evaluated the effect of exercise training on the LV systolic and diastolic function in patients with T2DM or obesity.
Methods: We included all randomized control trials (RCTs) that evaluated the effect of exercise training on cardiac structure and function among obese or T2DM patients. Primary outcome of interest was change in cardiorespiratory fitness (peak oxygen uptake, ml/kg/min) and measures of left ventricular systolic (global longitudinal strain) and diastolic function (early diastolic velocity, e`).
Results: The study included 484 patients who were enrolled in 8 RCTs. In the pooled data analysis, patients with T2DM or obesity undergoing exercise training had significant improvements in peak oxygen uptake [Weighted Mean Difference (WMD): 1.30 (95%CI: 0.55 to 2.04)]. Among echocardiographic outcomes, exercise training participants had modest but statistically significant improvements in early diastolic velocity [WMD (95% CI): 0.46 (0.01 to 0.09)], and global longitudinal strain [WMD (95% CI): 0.62 (0.04 to 0.09)] as compared with control group participants (Figure).
Conclusion: Exercise training in patients with T2DM or obesity is associated with a significant improvement in cardiorespiratory fitness and modest improvements in echocardiographic measures of systolic and diastolic function. These findings suggest that exercise training may improve subclinical systolic and diastolic dysfunction in patients at risk for HF in later life.
Author Disclosures: V. Anand: None. A. Pandey: None. S. Garg: None.
- © 2015 by American Heart Association, Inc.