Abstract 13077: Maternal and Fetal Outcomes Among Pregnant Women With Frequent Premature Ventricular Complexes
Introduction: Premature ventricular complexes (PVCs) in pregnancy are being increasingly recognized and many women have associated symptoms. Although thought to be benign, there is limited data on maternal and fetal outcomes in pregnancies with frequent PVCs. The objectives of this study were to describe the PVC burden and patterns, and to assess maternal and fetal outcomes in pregnancies with frequent PVCs.
Methods: In this prospective observational cohort study, 40 consecutive pregnancies referred to our institution between January 2010 and March 2015 with PVC burden of greater than 0.1% on Holter studies were included. We reviewed electrocardiograms to identify PVC morphologies and Holter studies to determine PVC burden. PVC burden were stratified into low (n = 20) and high (n = 20) severity based on the median PVC burden of 6.8%. Student’s t-tests and Fisher’s exact test were used to evaluate difference in maternal and fetal outcomes by severity of PVC burden and beta-blocker (BB) use. Paired t-test was used to compare changes in PVC burden from antepartum to postpartum. Pearson analysis was performed to evaluate correlation between PVC burden and cardiac function.
Results: Antepartum palpitations, pre-syncope, congestive heart failure, syncope, and deterioration in NYHA class were present in 70%, 25%, 5%, 2.5%, and 10% respectively. Fifty-five percent continued to have palpitation postpartum. Ninety-two percent of PVCs originated from right ventricular outflow tract. PVC burden decreased from 9.3 ± 9 % antepartum to 3.9 ± 5.4 % postpartum (p = 0.118). There was no correlation between PVC burden and left ventricular end diastolic and end systolic dimensions, and left ventricular ejection fraction (r = 0.08, p = 0.74; r = 0.03, p = 0.92; r = -0.16, p = 0.50). Gestation at delivery was 39 ± 2 weeks with newborn weight of 3251 ± 576 grams. APGAR scores at 1 and 5 minutes were 8 ± 2 and 9 ± 1 respectively. One newborn had intrauterine growth restriction and 3 had meconium liquor. There was no difference in the above outcomes in subgroup analyses based on severity of PVC burden and BB use.
Conclusions: Maternal and fetal outcomes in pregnancies with frequent PVCs were favorable. Severity of PVC burden and BB use did not have significant impact on maternal and fetal outcomes.
Author Disclosures: C. Tong: None. M.W. Deyell: None. M. Wheeler: None. M. Kiess: None. V. Rychel: None. J. Grewal: None.
- © 2015 by American Heart Association, Inc.