Abstract 12898: Cigarette Smoking is Associated With Rapid Renal Function Decline in African Americans in The Jackson Heart Study
Background: Controversy exists regarding the association of cigarette smoking and renal dysfunction, particularly among African Americans who are disproportionately affected by chronic kidney disease (CKD). Therefore, we evaluated the relationship between cigarette smoking and rapid renal function (RRF) decline in the Jackson Heart Study (JHS).
Methods: We evaluated the rates of RRF decline among a cohort of 5,301 African Americans enrolled as part of the JHS. Of those, 3648 with baseline creatinine were included for study. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation. RRF decline was defined as an absolute decline of 30% over 10 years. Smoking status was defined as current, past (smoked at least 400 cigarettes/life) or never smoker. Poisson regression models were performed to estimate the association of smoking status with RRF decline.
Results: There were 422 current, 659 past and 2567 never smokers identified at Visit 1. After adjustment for age, gender, BMI, diabetes, hypertension and total cholesterol, current smokers demonstrated a significantly higher incidence of RRF decline compared with never smokers (IRR 1.86, 95% CI 1.35-2.56). Current smokers using 1-19 cigarettes daily and ≥20 cigarettes daily also had an increased incidence of RRF decline (IRR 1.73, 95% CI 1.18-2.54 and IRR 2.03, 95% CI 1.23-3.35, respectively). There was a significant, stepwise reduction in eGFR from Visit 1 to Visit 3 in current and past smokers compared to never smokers (Figure).
Conclusions: In a large cohort of African Americans, current cigarette smoking was independently associated with RRF decline in a dose-dependent manner.
Author Disclosures: M.E. Hall: None. W. Wang: None. A. Penman: None. V. Okhomina: None. A.W. Dreisbach: None. L.A. Juncos: None. J.E. Hall: None. M.D. Winniford: None. B.A. Young: None.
- © 2015 by American Heart Association, Inc.