Abstract 12875: Serum Neutrophil Gelatinase-associated Lipocalin Has a Predictive Value for the Neurological Outcome of Post Cardiac Arrest Victims
Introduction: Neutrophil gelatinase-associated lopocalin (NGAL) is well known as the biomarker of acute kidney injury. Currently, serum NGAL is reported as the biomarker which is associated with mortality and multiple organ dysfunction syndrome in septic patients. In this study, we measured serum NGAL in post cardiac arrest syndrome (PCAS) patients to investigate the predictive value of neurological outcome.
Hypothesis: Serum NGAL is associated with favorable neurological outcome of PCAS patients.
Methods: 43 cases of PCAS patients were measured serum NGAL on day 1 and 2, and serum neuron specific enolase (NSE) was also measured on day 2. Patients were divided into two group (group G: CPC 1-2 and group P: CPC 3-5, CPC: cerebral performance categories). Serum NGAL and NSE were compared between group G and P. Receiver operation characteristic (ROC) curve analysis were performed of both NGAL and NSE.
Results: Group G (n = 20) and P (n = 23) were analyzed. Serum NGAL showed significant difference in day 2 (G: 282±116 ng/mL v.s. P: 299±87 ng/mL in day1: P = 0.609, G: 185±124 ng/mL v.s. P: 353±110 ng/mL in day 2: P<0.001). The ROC curve analysis showed area under the curve of NGAL in day 2 was 0.871, and the area of NSE in day2 showed 0.918.
Conclusions: Serum NGAL in PCAS patients had the predictive value for neurological outcome which is comparable to serum NSE.
(This study was supported by grants from Japanese Ministry of Health, Labour and Welfare: No. 25462824)
Author Disclosures: T. Kaneko: None. M. Fujita: None. Y. Ogino: None. H. Irie: None. S. Iwashita: None. R. Karashima: None. M. Kamikawa: None. H. Tanaka: None. R. Tsuruta: None. S. Kasaoka: None.
- © 2015 by American Heart Association, Inc.