Abstract 12834: Effects of Different Targeted Temperature on the Outcomes of CPR in a Rat Model of Cardiac Arrest
Introduction: Therapeutic hypothermia improves the outcomes following resuscitation. The current hypothermia range (32-34°C) recommended by the American Heart Association is based mainly on two clinical studies. The benefits and the adverse effects of the temperature management at this range are still controversial. In the present study, we compared the effects of different body temperatures (33°C, 36°C, 37°C and 38°C) after resuscitation on the outcomes of CPR in a rat model of cardiac arrest.
Methods: Ventricular fibrillation was electrically induced and untreated for 8 mins. Defibrillation was attempted after 8 mins of CPR. The animals were then randomized into 4 groups (n=10): hypothermia at 33°C (T33), hypothermia at 36°C (T36), normothermic (T37) and hyperthermia (T38). The variable core temperatures were maintained for 6 hours. Myocardial function and sublingual microcirculation were measured at baseline, 1, 2, 3 and 6 hours after the return of spontaneous circulation (ROSC). Survival and neurological function were evaluated at 24, 48 and 72 hours after ROSC.
Results: The measurements were significantly better in the animals treated with hypothermia regardless of the cooling depth when compared with the normothermic group. Better sublingual microcirculation at 6 hours post-resuscitation was observed in the T36 group when compared with the T33 group. Significantly worse myocardial function and sublingual microcirculation were observed in the T38 animals when compared to the T37 group.
Conclusions: Mild reduction of core temperature to 36°C early after ROSC improved post-resuscitation myocardial and neurological functions and survival to the same extent as 33°C but with less impairment of microcirculation.
Author Disclosures: Z. Tang: None. Z. Yang: None. J. Wang: None. L. Yin: None. S. Zhao: None. X. Wu: None. J. Kline: None. W. Tang: None.
- © 2015 by American Heart Association, Inc.