Abstract 12750: Exercise Ventilatory Power in Heart Failure. Definition of Functional and Hemodynamic Patterns by Cardiopulmonary Exercise Testing and Stress Echocardiography
Exercise Ventilatory Power (EVP; peak systolic blood pressure/exercise ventilation to CO2 production slope) is a new powerful prognostic marker that combines ventilator abnormalities with systemic hemodynamic during exercise. The phenotype and clinical relevance of patients with a worse EVP is broadly undefined and we aimed at this definition across a population of heart failure reduced ejection fraction (HFrEF) of different severity.
Methods: 77 HFrEF patients (mean age 65±11; male 70%; ischemic etiology 59%; NYHA class I, II, III and IV 23%, 33%, 31% and 13%, respectively; mean LVEF 34±9 %) underwent cardiopulmonary exercise test (CPET) evaluation (ramp protocol on performed on a tilt-table cycleergometer) combined with simultaneous echocardiographic assessment.
Results: Patients were divided in 2 EVP classes (cutoff 3) focusing on peak exercise echocardiographic variables.
Conclusions: A low EVP translates in a very unfavorable phenotype characterized by a lower peak VO2 and CO response at peak exercise. Remarkable impairment in right heart function and pulmonary hemodynamics were also peculiar of a low EVP. All the LV-pulmonary circulation- RV apparatus is abnormally involved in the exercise response of the EVP HFrEF phenotype.
Author Disclosures: V. Labate: None. G. Generati: None. M. Pellegrino: None. F. Bandera: None. M. Guazzi: None.
- © 2015 by American Heart Association, Inc.