Abstract 12387: Comparison of Brain Injury and Quantitative Eeg Measures After Ventricular Fibrillation and Asphyxial Cardiac Arrest
Introduction: Electroencephalography (EEG) is widely used to assess neurological prognosis in patients who are comatose after cardiac arrest. However, different mechanisms of cardiac arrest cause different morphologic patterns of brain injury. In the present study, we compared postresuscitation brain injury and characteristics of EEG between animals resuscitated from cardiac arrest induced by ventricular fibrillation (VF) and asphyxiation (AS).
Methods: Thirty-two healthy adult Sprague-Dawley rats of both sexes were randomized to either VF or AS. For animals assigned to VF, cardiac arrest was induced through high frequency transesophageal cardiac pacing and untreated for 5 mins. After 2 mins of cardiopulmonary resuscitation (CPR), a 2-J biphasic defibrillation shock was delivered. For AS, cardiac arrest was induced by airway obstruction, and CPR was initiated after pulselessness was maintained for 5 mins. Serum level of S100B were measured at baseline, 2 and 4 hrs postresuscitation. EEG were continuously measured for 4 hrs and was quantified by information quantity entropy (IQE).
Results: There were no significant difference in body weight, baseline heart rate, mean arterial pressure and ejection fraction measurement. All of the animals were successfully resuscitated. However, duration of CPR (72±28 s vs. 200±59 s, p<0.001) was significantly shorter in AS group. Figure 1 shows the S100B (A) and IQE (B) measurement before and after resuscitation. Brain injuries were severe while EEG measures were lower in the AS group during the postresuscitation period. This was associated with considerably lower 96 hrs survival rate (25.0% vs. 87.5%, p<0.001) compared with VF.
Conclusion: In this rat model, both VF and AS cardiac arrests caused brain injuries. Compared with VF, AS caused more severe brain injury and associated with lower survival rate. Quantitative EEG analysis was prognostic for neurological outcome when mechanisms of cardiac arrest was different.
Author Disclosures: Y. Li: None. P. Wang: None. B. Chen: None. M. He: None.
- © 2015 by American Heart Association, Inc.