Abstract 12188: Combined Effect of BMI and Renal Function on Long-term Clinical Outcomes in the Elderly Following Percutaneous Coronary Intervention
Introduction: Accompanied by aging society, percutaneous coronary intervention (PCI) has been widely performed in the elderly for the past few decades. However, a paucity of data examining clinical features and outcomes is available. Previously, low body mass index (BMI) and renal insufficiency were demonstrated to be negative predictors in patients with coronary artery disease. However, the effect of BMI and renal insufficiency on clinical outcome in elderly following PCI was not fully examined.
Methods: We analyzed data of patients with the age of 70 to 85 following PCI in Juntendo University (Tokyo, Japan) from 1985 to 2010. Cox regression analysis was performed to assess an effect of combination with BMI less than 22 and eGFR less than 60 on all-cause mortality that was evaluated at 3-year after the index PCI.
Results: Of 3824 patients, 1019 patients with the age of between 70 and 85 were examined. Mean age, BMI and eGFR were 75.2, 23.3 and 59.6, respectively. The population was divided into 3 groups according to the value of BMI and eGFR (BMI < 22 and eGFR < 60; high risk, BMI < 22 or eGFR < 60; intermediate risk, BMI ≥ 22 and eGFR ≥ 60; low risk). The higher incidence of all-cause mortality was observed in accordance with the greater risk determined by BMI and eGFR (P for trend < 0.0001) (Figure 1). Kaplan-Meier estimation for all-cause mortality was significantly different between the three groups (Figure 2). In multivariable Cox regression analysis including traditional coronary risk factors, combined effect of BMI and eGFR was associated with all-cause mortality.
Conclusions: Combination of BMI and eGFR was independently associated with all-cause mortality in the elderly following PCI.
Author Disclosures: R. Naito: None. K. Miyauchi: None. J. Shitara: None. H. Endo: None. H. Wada: None. S. Doi: None. H. Konishi: None. S. Tsuboi: None. M. Ogita: None. T. Dohi: None. T. Kasai: None. H. Tamura: None. S. Okazaki: None. K. Isoda: None. H. Daida: None.
- © 2015 by American Heart Association, Inc.