Abstract 12158: Impact of Modifiable Risk Factors on Circulating Concentrations of B-type Natriuretic Peptide and Cardiac Troponin T
Introduction: Alcohol use, physical activity, diet, and cigarette smoking are modifiable cardiovascular risk factors that have a substantial impact on the risk of myocardial infarction, stroke, and cardiovascular death.
Hypothesis: We hypothesized that these behaviors may alter concentrations of cardiac troponin, a marker of myocyte injury, and B-type natriuretic peptide, a marker of myocyte stress. Both markers have shown strong association with adverse cardiovascular outcomes.
Methods: In 564 women with no evidence of cardiovascular disease, we measured circulating concentrations of cardiac troponin T, measured using a high-sensitivity assay (hsTnT), and the N-terminal fragment of B-type natriuretic peptide (NT-proBNP). We used logistic regression to determine if these behaviors were associated with detectable hsTnT (>= 3ng/L) or with NT-proBNP in the highest quartile (≥117.4 ng/L).
Results: The median (Q1-Q3) NT-proBNP of the cohort was 64.2 (37.8-117.4), and 30.3% (171/564) of the cohort had detectable circulating hsTnT. In adjusted models, women who drank 1-6 drinks per week had a lower odds of having a detectable hsTnT (OR 0.54, 95% CI: 0.33-0.89, P-trend=0.001) or an elevated NT-proBNP (OR 0.48, 95% CI 0.19-1.19, P-trend =0.03; Figure). We validated the results for B-type natriuretic peptide in a large independent cohort. No significant associations were seen for diet, exercise, or smoking.
Conclusion: Regular alcohol consumption is associated with lower concentrations of hsTnT and NT-proBNP, two cardiovascular biomarkers associated with increased cardiovascular risk. These results raise the hypothesis that the beneficial effects of alcohol consumption may be mediated by direct effects on the myocardium.
Author Disclosures: P.K. Srivastava: None. A.D. Pradhan: None. N.R. Cook: None. P.M. Ridker: None. B.M. Everett: Research Grant; Significant; Roche Diagnostics: Investigator-Initiated Research Grant, Novartis: Research Grant.
- © 2015 by American Heart Association, Inc.