Abstract 11818: Mitral Valve Repair for Secondary Mitral Regurgitation In Non-ischemic Dilated Cardiomyopathy is Associated With Left Ventricular Reverse Remodelling and Increase of Forward Flow
Introduction: It remains unclear whether surgical or transcatheter mitral valve repair for secondary mitral regurgitation (MR) in patients with non-ischemic cardiomyopathy reverse the underlying left ventricular (LV) pathophysiology. Accordingly, the present study evaluated the effect of mitral valve repair on LV performance in this subset of patients.
Methods: Seventy-six patients (65±14 years old, 43% male) with non-ischemic cardiomyopathy and moderate to severe chronic secondary MR treated successfully with transcatheter or surgical mitral valve repair were evaluated. Transthoracic echocardiography was performed at baseline, discharge and 6-months post-repair.
Results: After mitral valve repair, LVEF and LV global longitudinal strain (GLS) corrected for LV end-diastolic volume remained unchanged over time (p=0.90 and p=0.96 respectively). In contrast, LV forward flow increased significantly over time (stroke volume index: from 20±7 to 29±8 and 26±8 ml/m2, p<0.001; cardiac index: from 1.50±0.44 to 2.36±0.60 and 2.01±0.48 L/min/m2, p<0.001) (Figure). In addition, LV end-diastolic and end-systolic volume index significantly reduced over time (from 87±42 to 70±33 and 75±39 ml/ m2, p<0.001; and from 60±35 to 50±30 and 53±36 ml/ m2, p=0.004, respectively). These changes were independent of the type of repair.
Conclusions: Surgical and transcatheter mitral valve repair for secondary MR in patients with non-ischemic dilated cardiomyopathy improved LV forward flow and induced LV reverse remodelling but did not change LV systolic function.
- Secondary mitral regurgitation
- Dilated cardiomyopathy
- Surgical mitral valve repair
- Speckle tracking echocardiography
Author Disclosures: V. Kamperidis: None. S.E. van Wijngaarden: None. P.J. van Rosendael: None. M.V. Regeer: None. F. van der Kley: None. G. Sianos: None. N. Ajmone Marsan: None. J.J. Bax: None. V. Delgado: Speakers Bureau; Modest; Abbott Vascular.
- © 2015 by American Heart Association, Inc.