Abstract 11724: Premature Atrial Contraction Frequency is not Associated With Cerebral Infarcts: The Atherosclerosis Risk in Communities (ARIC) Study
Background: Premature atrial contractions (PACs) have been shown to predict incident atrial fibrillation (AF). However, the association between PAC frequency and risk of ischemic stroke is less well-characterized. We evaluated the cross-sectional association between PAC frequency and cerebral infarcts on brain MRIs in a sample of participants from the ARIC study, a community-based prospective cohort study.
Hypothesis: We hypothesized that higher PAC frequency is associated with higher odds of cerebral infarcts.
Methods: We included 323 (mean age [SD], 78.8 [5.1] years; 52.9% female) participants who underwent brain MRI scans, and ≥2 days of heart rhythm recording using the Zio®Patch (a non-invasive, 2-week continuous ECG monitor) in July 2013-March 2014. PAC frequency was defined as the number of PACs per hour, averaged over the entire monitoring period. Definitions of MRI-diagnosed brain infarcts are given in the Table . We used multivariable logistic regression to assess the association of PAC frequency tertiles with cerebral infarcts on MRI scans.
Results: The mean wear and analysis time of the Zio®Patch were 13.1 [2.1] and 12.7 [2.3] days, respectively. Twenty-six (8%) participants had AF detected by the Zio®Patch. Higher PAC frequency was not associated with higher odds of cerebral infarcts (Table). A sex- and age-adjusted logistic regression modeling PAC frequency with a restricted cubic spline confirmed the lack of association with cerebral infarcts.
Conclusions: Although PACs are a precursor to AF, and the risk factors for PACs are largely similar to AF, higher PAC frequency is not related to higher odds of cerebral infarcts. This finding suggests that the disorganized rhythm of AF or the presence of some other factor such as left atrial enlargement or dysfunction may be necessary for the pathogenesis of ischemic stroke.
Author Disclosures: L.Y. Chen: None. S.K. Agarwal: None. F.L. Norby: None. R.F. Gottesman: None. L.R. Loehr: None. E.Z. Soliman: None. T.H. Mosley: None. A.R. Folsom: None. J. Coresh: None. A. Alonso: None.
- © 2015 by American Heart Association, Inc.