Abstract 11682: Prognostic Impact of Periodic Leg Movements in Hospitalized Heart Failure Patients
Background: Periodic leg movements during sleep (PLMs) are the disorder characterized by regularly recurring movements of the legs during sleep. Recently, it has been reported that PLMs have a critical association with cardiovascular mortality and morbidity. However, the prevalence and impact of PLMs on cardiac and all-cause mortality still remain unclear in patients with heart failure (HF). Methods and Results: Consecutive 114 patients admitted for treatment of HF and underwent polysomnography were divided into two groups based on PLM index: moderate-severe PLMs group (PLM index ≥ 20/h, n = 24) and non-mild PLMs group (PLM index < 20/h, n = 90). We compared patient characteristics, findings of echocardiography and cardio-pulmonary exercise test between the two groups. Furthermore, we prospectively followed cardiac events including cardiac death and all-cause mortality. The moderate-severe PLMs group, as compared to non-mild PLMs groups, had lower levels of estimated GFR (46.8 vs. 59.5 ml/min/1.73cm2, P = 0.032) and tended to have lower peak VO2 (14.5 vs. 16.3 ml/min/kg, P = 0.09). In contrast, age, body mass index, systolic blood pressure, B-type natriuretic peptide, hemoglobin, sodium, C-reactive protein and left ventricular ejection fraction were similar between the two groups. Importantly, cardiac mortality (log-rank P = 0.005) and all-cause mortality (P = 0.028) were higher in moderate-severe PLMs group than in non-mild PLMs group (Figure). In the multivariable Cox proportional hazard analyses, after adjusting for potential confounding factors, PLM index was an independent predictor of cardiac (HR 1.024, 95% CI 1.006-1.042, P = 0.009) and all-cause mortality (HR 1.016, 95% CI 1.001-1.031, P = 0.045) in HF patients. Conclusions: The PLM index was a novel predictor of cardiac and all-cause mortality in HF patients.
Author Disclosures: Y. Kanno: None. A. Yoshihisa: None. M. Takiguchi: None. S. Miura: None. A. Sato: None. T. Shimizu: None. Y. Nakamura: None. H. Yamauchi: None. T. Owada: None. S. Abe: None. S. Suzuki: None. M. Oikawa: None. N. Sakamoto: None. T. Yamaki: None. K. Sugimoto: None. H. Kunii: None. K. Nakazato: None. H. Suzuki: None. S. Saitoh: None. Y. Takeishi: None.
- © 2015 by American Heart Association, Inc.