Abstract 10931: Serum Mac-2 Binding Protein May be a Potential Biomarker for Diagnosis of Silent Atherosclerosis in Subjects With Cardiovascular Risk Factors
Introduction: Mac-2 binding protein (M2BP) is secreted from many cell types. Recently, serum M2BP levels were reported to be useful as a glycoprotein biomarker for liver fibrosis and several types of malignant tumors.
Hypothesis: We hypothesized that expression of M2BP might change in the process of atherosclerosis. Hence, the present study was designed to investigate a possible association of the serum M2BP level with cardiovascular risk factors and whether M2BP is a candidate for a marker of progression of atherosclerosis.
Methods: Outpatients with one or more cardiovascular risk factors (n=156) and healthy controls without cardiovascular risk factors (n=20) were enrolled. Subjects with liver dysfunction, a history of hepatic disease, malignant neoplasm, or cardiovascular events were excluded. Blood was sampled and serum levels of hyperglycosylated-M2BP were measured by glycan-based immunoassay. Vascular function was assessed by pulse wave velocity (PWV) and flow-mediated dilation (FMD).
Results: Serum M2BP levels were positively correlated with cardiovascular risk factors (age, BMI, systolic blood pressure, fasting blood sugar, and HbA1c) and inversely correlated with HDL-cholesterol and estimated-GFR. The M2BP levels were also correlated with CRP, urinary albumin to creatinine ratio, and PWV. The M2BP levels in subjects with hypertension, dyslipidemia, or abnormal glucose metabolism were higher than those in subjects without hypertension, dyslipidemia, or abnormal glucose metabolism (P<0.01, respectively). Moreover, the M2BP levels were associated with accumulation of cardiovascular risk factors. Multiple logistic regression analysis with endpoint of high M2BP (above mean value) revealed that hypertension and dyslipidemia were significantly associated with high M2BP. Subjects with high M2BP showed significantly decreased FMD than those with low M2BP (p<0.05).
Conclusions: Serum M2BP levels were increased with age and accumulation of cardiovascular risks factors. Although the spectrum was narrow as compared to that in cases of hepatic fibrosis, significant correlations with cardiovascular risk markers suggest that serum M2BP reflects silent atherosclerosis in subjects with cardiovascular risk factors.
Author Disclosures: T. Sugiura: None. Y. Dohi: None. S. Yamashita: None. Y. Tanaka: None. N. Ohte: None.
- © 2015 by American Heart Association, Inc.