Abstract 10871: Changes in Lipid Profile of Obese Patients Following Contemporary Bariatric Surgery: A Meta-Analysis
Background: Dyslipidemia drives the development of atherosclerosis and obese individuals frequently manifest dyslipidemia. Although metabolic surgery was originally performed to treat hypercholesterolemia, the effect of contemporary bariatric surgery on serum lipids has not been systematically characterized.
Methods: We queried MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials from inception through the second week of May, 2015 for studies with at least 20 obese adults who underwent Roux-en-Y Gastric Bypass (RYGBP), Adjustable Gastric Banding, Bilio-Pancreatic Diversion (BPD), or Sleeve Gastrectomy reporting lipid data at baseline and at least one year following surgery. Primary outcome measures were change in total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglyceride values from baseline to 1-year follow-up after bariatric surgery.
Results: There were 180 articles eligible for inclusion with 25,189 obese subjects (mean body mass index 45.1±4.8 kg/m2) and over 47,800 patient-years follow-up. In patients who underwent surgery, compared to baseline, there were significant reductions in TC, LDL-C, triglycerides and a significant increase in HDL-C (P<0.00001 for all), although the magnitude of change varied with surgical type (Pinteraction <0.05; Figure). The magnitude of the change in lipid parameters with surgery (overall) was significantly greater than the change in lipid parameters among patients who did not undergo surgery (Figure). Results were similar beyond one year.
Conclusions: Contemporary bariatric surgical techniques produce significant improvements in lipid parameters at one year following surgery, which are greater in magnitude than those in patients not undergoing surgery. However, the magnitude of change in lipid parameters varies widely with surgical type, indicating that these differences may be relevant in deciding the most appropriate technique for a given patient.
Author Disclosures: S.P. Heffron: None. A. Parikh: None. A. Volodarskiy: None. C. Ren-Fielding: Consultant/Advisory Board; Modest; Apollo Endosurgery. A. Schwartzbard: None. J. Nicholson: None. S. Bangalore: None.
- © 2015 by American Heart Association, Inc.