Abstract 10277: Effect of CoQ10 on Contractile Reserve of Hibernating Swine Myocardium Following Bypass Surgery
Background: We have previously shown that the recovery of regional function and maximal oxygen consumption in a pig model of hibernating myocardium is incomplete at 4 weeks following bypass surgery (CABG). Because clinical studies suggest a beneficial effect of chronic administration of Coenzyme Q10 (CoQ10) in ischemic heart disease, we tested the benefit of this supplement on contractile reserve, using MRI.
Methods: Twelve pigs underwent placement of a constrictor around the LAD artery and had reduced function by MRI at 12 weeks. They then underwent off-pump byass using a left internal mammary artery graft and were allowed to recover. Pigs were given daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo and restudied with MRI at 4 weeks post-CABG. Images were acquired prior to and following CABG with a 3.0-T scanner (Achieva, Philips Medical Systems, Andover MA, USA), with a 4-element phased array coil on the chest and EKG gating. Regional circumferential strain (EC) measures were determined at baseline and at the time of the final study post-CABG, during an infusion of low dose dobutamine. Immediately post-stress, blood samples were obtained for analysis of troponins.
Results: One animal did not survive and comparisons are made between the Placebo (N=6) and CoQ10 (N=5) groups. At 12 weeks following instrumentation and just prior to CABG, strain in the LAD region of all animals was lower than the remote regions at rest (-14.27±0.65 versus -15.13±0.69 P<0.05). At 4 weeks post-CABG, baseline strain in placebo and CoQ10 groups was -12.4±1.2 and -13.7±0.8 respectively (NS). In addition to no differences in basal function, there were no intergroup differences in either contractile reserve in the LAD region, as measured by circumferential strain, or cardiac troponin levels post-stress (Figure). In summary, in this model of chronic myocardial ischemia, daily supplementation with CoQ10 did not improve basal function or contractile reserve at 4 weeks following CABG.
Author Disclosures: L. Hocum Stone: None. C. Duffy: None. T.A. Butterick: None. C. Holley: None. M. Crampton: None. H.B. Ward: None. C. Swingen: None. R.F. Kelly: None. E.O. McFalls: None.
- © 2015 by American Heart Association, Inc.