Abstract 10208: Differences in Natriuretic Peptide Levels by Race/Ethnicity in the Multi-Ethnic Study of Atherosclerosis
Introduction: Natriuretic peptides (NP) are cardiac-derived hormones with favorable cardio-metabolic actions including natriuresis, diuresis, and vasodilation. Low NP levels have been associated with increased risks of hypertension and diabetes, conditions with variable prevalence by race/ethnicity. Heritable factors underlie a significant proportion of the inter-individual variation in NP levels, but the specific influence of ancestry is unknown.
Methods: In 4,162 individuals (40% White, 24% Black, 23% Hispanic, and 13% Chinese) without prevalent cardiovascular disease at baseline (2000-2002) in the Multi-Ethnic Study of Atherosclerosis, multivariable adjusted linear regression and restricted cubic splines were used to examine differences in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) levels according to self-reported race/ethnicity or ancestry determined from genetic ancestry informative markers.
Results: NT-proBNP levels were significantly lower in Black and Chinese individuals than in White individuals, and were intermediate in Hispanics (Figure 1). Self-identified Blacks and Hispanics were the most genetically admixed groups. Among individuals self-identified as Black, a 1 standard deviation (14%) increase in genetic European ancestry was associated with 8% higher (95%CI, 1 to 16%) NT-proBNP. Among Hispanic individuals, genetic European ancestry was also positively associated with NT-proBNP levels, while African ancestry was negatively associated with NT-proBNP (Figure 2).
Conclusions: NP levels differ substantially according to race/ethnicity, with the lowest levels among Black and Chinese individuals. Racial/ethnic differences in NP levels appear to have a genetic basis, with European and African ancestry associated with higher and lower NT-proBNP levels, respectively. Relatively low NP levels may, in part, contribute to racial/ethnic disparities in cardio-metabolic disease susceptibility.
Author Disclosures: D.K. Gupta: None. L.B. Daniels: None. S. Cheng: None. C. DeFilippi: None. M.H. Criqui: None. A. Maisel: None. J.A. Lima: None. H. Bahrami: None. P. Greenland: None. M. Cushman: Research Grant; Significant; Diadexus. Honoraria; Significant; Diadexus. R. Tracy: None. D. Siscovick: None. A. Bertoni: None. J. Carr: None. T.J. Wang: Other Research Support; Modest; Diasorin. Consultant/Advisory Board; Modest; Takeda.
- © 2015 by American Heart Association, Inc.