Abstract O.63: Novel Use Of Fractal Analysis In Kawasaki Disease For Risk Prediction
Introduction: Fractal based analysis of vascular branching complexity is known to have a prognostic role in cardiovascular risk prediction and suboptimal Fractal Dimensions of retinal vessels has been shown to correlate with coronary mortality. We hypothesize that Kawasaki disease permanently alters the fractal pattern of the retinal vasculature reflecting suboptimal microcirculatory development and attendant coronary risk.
Objectives: We calculated and compared the Zone Fractal Dimension(Df) of children with a history of Kawasaki disease with a matched cohort
Methods: All subjects underwent high resolution digital retinal photography and disc-as well as macular centered photographs were digitized and used for measurement of Df using a standardized validated program performed by a single trained grader. Retinal vascular dimensions were also measured
Results: Fifty subjects and 100 controls were examined. Subjects had a Df f 1.506 while controls had a Df of 1.432(P<0.001). Cases were controlled for age, gender and ethnicity.
Conclusion: In adult studies, a Df exceeding 1.47 has been shown to be sub-optimally high with resultant associated coronary risk. This suggests that the long term cardiovascular risks of Kawasaki disease may not only be conferred through coronary flow factors but systemic microcirculatory mal-development.
Author Disclosures: T. Lim: None. C. Cheung: None. S. Quek: None. P. Ong: None. I. Wong: None. R. Grignani: None. T. Wong: None.
- © 2015 by American Heart Association, Inc.