Abstract 92: Evaluation Of The Ascending Aorta Stifness Following Kawasaki Disease In Compraison With Systemic Hypertension
Background: Kawasaki Disease (KD) is a systemic vasculitis that affects large and medium-size arteries. The coronary arteries draw most of the clinical attention whereas few studies have taken interest in involvement of other vessels. Using an imaging-based mechanical biomarker (ImBioMark), we measured the ascending aorta (AA) stiffness in pediatric KD subjects compared to healthy controls (CTL) and patients with systemic hypertension (HTN).
Methods: We evaluated AA (Fig. 1a) in 20 CTL, 12 KD subjects (4 with and 8 without CA aneurysms). 8 children with HTN represented a comparative clinical model of vascular stiffness. We measured systolic and diastolic AA strains using ImBioMark. Strain was tested for normality against height for CTL. Strain values from KD and HTN subjects were normalized (Z-score) according to height. Comparisons were performed between groups using non-parametric statistics.
Results: Systolic and diastolic pressures were normal in KD subjects (49.8±28.4 and 46.1±6.9 percentile, respectively). Age was similar between KD (9.1±5.3 yo) and HTN (9.9±5.3 yo), p=NS. Fig. 1b exhibits a strain curve computed with ImBioMark. Systolic and diastolic strain values were normally distributed against height in CTL. HTN subjects had abnormal systolic and diastolic strain values. KD subjects had normal diastolic strain, but significantly abnormal systolic strain (Fig. 2). There was no statistically significant difference in strain, based on the presence or absence of CA aneurysm.
Conclusion: Despite normal blood pressure, AA in KD exhibited reduced strain during systole. This may reflect in situ rigidity of the AA.
Author Disclosures: R. Maurice: None. I. Nandlall: None. A. Fournier: None. N. Dahdah: None.
- © 2015 by American Heart Association, Inc.