Abstract 64: Correlation Of The Platelet Count With Immunoglobulin G, M, And A Levels In The Early Convalescent Stage Of Kawasaki Disease
Background: The clinical course of Kawasaki disease (KD), which is self-limiting and immune-mediated, is controlled by the host’s immune system. The incidence of incomplete KD is increasing in Korea. We evaluate the changes in the platelet count and immunoglobulin (Ig) levels (IgG, IgM, IgA, and IgE) during hospitalization and the relationships among these parameters.
Methods: We examined the platelet count and levels of the four above-mentioned Igs twice at presentation and at discharge (mean of 6.2 days apart) in 43 patients with complete KD who received intravenous Ig at 2 g/kg. The relationships across all parameters were evaluated.
Results: The mean patient age was 29.9 ± 16.4 months, and there were 28 male and 15 female patients. The mean platelet count and IgG, IgM, IgA, and IgE levels at presentation and at discharge were 366 ± 92 and 548 ± 135 х103/μL, 718 ± 317 and 2433 ± 426 mg/dL, 125 ± 45 and 234 ± 71 mg/dL, 63 ± 57 and 98 ± 79 mg/dL, and 69 ± 70 and 57 ± 64 IU/mL, respectively. The values of these parameters were correlated with the time of examination from fever onset, in comparing three groups with fever duration of the <5 days, the 5-10 days, and the 11-16 days (Nonparametric Kruskal Wallis test and Dunn’s mehod for each post-hoc pair-wise test). A correlation was also noted in the degree of increase calculated at the two time points between the platelet count and IgG (P = 0.002), IgM (P = 0.01) or IgA level (P = 0.002), respectively (Spearman correlation coefficient).
Conclusions: The platelet count and Ig levels (IgG, IgM, and IgA) increased in the early convalescent stage of KD and were correlated with each other. This finding suggests that the host’s immune/repair system is involved in recovery from KD and may help to differentiate KD, especially incomplete KD, from other KD-like diseases if these phenomena do not occur in other diseases.
Author Disclosures: K. Lee: None.
- © 2015 by American Heart Association, Inc.