Abstract 53: Tenascin-C Expression in Cardiovascular Lesion of Kawasaki disease.
Background: Tenascin-C (TN-C) is an extracellular matrix that is closely associated with tissue remodeling and inflammation. It is expressed under pathological condition such as myocarditis, myocardial infarction, atherosclerosis and aneurysm. However, examination of TN-C expression in Kawasaki disease (KD) has not been yet performed.
Materials and methods: The tissue samples of myocardium and coronary arteries were obtained from 25 autopsy cases of KD(age: 3 months to 20 years old, sex: 18 males and 7 females, duration of the illness: 6 days to 17 years). Histological findings of the myocardium and coronary artery were analyzed and correlated with TN-C expression by immunohistochemistry.
Results: 1) Myocardium: Myocarditis was observed in 8 KD patients who died within 33 days after the onset. On the other hand, chronic persistent myocarditis and post-inflammatory myocardial fibrosis were not seen in the patients who died after 33th day of the disease. Myocardial infarction was observed in 9 patients who died in the convalescent and remote phases of KD. Expression of TN-C in the myocardium corresponded to the area with inflammatory cell infiltration and granulation tissue. The degree of expression correlated with the severity of the inflammation.
2) Coronary artery: Intense TN-C expression was observed at the site of active inflammation of coronary arteries in acute stage. Regarding convalescent period (27 to 57 days after the onset) when the inflammation began to disappear, the TN-C expression still remained in the intima and media but weakened in the adventitia and surrounding connective tissue. In remote phase, TN-C expression was limited to the neovascular vessels in the thickened intima and recanalized vessels.
Conclusion: The results of this histological study demonstrate that TN-C may be a useful biomarker for indicating in KD cardiovascular lesions.
Author Disclosures: Y. Yokouchi: None. T. Oharaseki: None. Y. Enomoto: None. S. Naoe: None. K. Imanaka-Yoshida: None. K. Takahashi: None.
- © 2015 by American Heart Association, Inc.