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Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Failure to honor embargo policies (http://newsroom.heart.org/newsmedia/embargo-policy) will result in the abstract being withdrawn and barred from presentation.
Poster Abstract PresentationsSession Title: Poster Session 1

Abstract 43: Real Time Polymerase Chain Reaction Assays For Detection Of Respiratory Viruses In Kawasaki Disease Patients

Young Mi Hong, Seul Bee Lee, Han Seul Choi, Jung Hyun Kwon, Hae Soon Kim, Sejung Son
Circulation. 2015;131:A43
Young Mi Hong
Ewha Womans Univ, Seoul, Korea, Republic of
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Seul Bee Lee
Ewha Womans Univ, Seoul, Korea, Republic of
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Han Seul Choi
Ewha Womans Univ, Seoul, Korea, Republic of
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Jung Hyun Kwon
Ewha Womans Univ, Seoul, Korea, Republic of
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Hae Soon Kim
Ewha Womans Univ, Seoul, Korea, Republic of
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Sejung Son
Ewha Womans Univ, Seoul, Korea, Republic of
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Abstract

Purpose: Respiratory symptoms are frequently observed in children with Kawasaki disease (KD) during the acute phase. The association rate of KD with antecedent respiratory illness has been reported to range from 56 to 83%. Clinical and epidemiologic features of KD support an infectious cause, but the etiology remains unknown. We investigated the association of respiratory viruses in children with KD using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR).

Methods: 138 KD patients were enrolled from January 2010 to June 2013. Two study groups (Group 1; n=94, KD without respiratory symptoms, Group 2; n=44, KD with respiratory symptoms) were compared with a control group (Group 3; n=5, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum total protein, albumin, C-reactive protein (CRP), NT-pro brain natriuretic peptide (BNP). Echocardiographic measurements were compared between the three groups. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses (corona virus, parainfluenza virus 1, 2 and 3, influenza A and B, respiratory syncytial virus A and B, rhino virus A, B and C, metapneumo virus, adenovirus, and bocavirus) in groups 2 and 3.

Results: The rate of KD with respiratory symptoms was 17.5%. The duration of fever was significantly longer and coronary artery diameter was significantly larger in group 2 than in group 1. Coronary artery diameter, CRP, platelet count, ALT, and NT-pro BNP were significantly higher and albumin lower in group 2 compared with group 3. Detection rate of adenovirus was 55.0% in group 2 and 28.6% in group 3.

Conclusion: A positive RT-PCR for respiratory viruses may be helpful to elucidate the specific virus in KD patients with respiratory symptoms. NT-proBNP is a very important diagnostic tool in differentiating KD from other febrile viral respiratory infaction.

  • Biomarkers
  • Natriuretic peptide
  • Echocardiography
  • Author Disclosures: Y. Hong: None. S. Lee: None. H. Choi: None. J. Kwon: None. H. Kim: None. S. Son: None.

  • © 2015 by American Heart Association, Inc.
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April 28, 2015, Volume 131, Issue Suppl 2
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    Abstract 43: Real Time Polymerase Chain Reaction Assays For Detection Of Respiratory Viruses In Kawasaki Disease Patients
    Young Mi Hong, Seul Bee Lee, Han Seul Choi, Jung Hyun Kwon, Hae Soon Kim and Sejung Son
    Circulation. 2015;131:A43, originally published June 29, 2015

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    Abstract 43: Real Time Polymerase Chain Reaction Assays For Detection Of Respiratory Viruses In Kawasaki Disease Patients
    Young Mi Hong, Seul Bee Lee, Han Seul Choi, Jung Hyun Kwon, Hae Soon Kim and Sejung Son
    Circulation. 2015;131:A43, originally published June 29, 2015
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