Abstract 15: Multicenter Kawasaki Disease Study In Children Of Argentina
Introduction: Kawasaki disease (KD) is a vasculitis that affects vessels of small and medium caliber.
Objectives: 1 Determine clinical and epidemiology of KD in children in 22 pediatric referral centers in Argentina. 2 Identify risk factors for coronary complications (CC).
Material and Methods: A retrospective and analytical study from 01/01/2010 to 31/12/2013. Variables: age, sex, heart rate (HR), clinic features, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), leukocytes (Gb), neutrophils, hemoglobin (Hb) and CC. Color Doppler echocardiography: acute phase and 4-6 weeks.
Results: Subjects: 191, age (Md) 29 months (R: 2-144) .Ratio v / m: 1.8 / 1. Clinical: fever 100% (191/191) more frequent and adenopatía: 57% (110/191) less frequent. CC: 15.7% (30/191). Mortality: 0.52% (1/191 cases). Increased risk of CC: leukocytosis> 20,000 / mm3 Odds ratio (OR) = 4.235 (95% CI 1704-10529). Hematocrit <30, OR = 6.042. (95% CI 2469-14782) p <0.0002; Hb <10 OR = 5.056 (95% CI 2163-11814) p 100 mm / 1h OR = 3.725 (95% CI 1642-8447) p 100 mg / dl OR = 6.417. (95% CI 2441-16869) p <0.0002 and other heart affections.OR = 7.964. (95% CI 2459-25794) p <0.0010. Children from the West of the country have 2.7 times greater risk of CC OR = 2.714 (95% CI: 1228-5997) p <0.019 compared to the rest.
Conclusions: Increased frequency in males. Increased risk of CHD in subjects from western Argentina. Low mortality. Increased risk of CC: low hematocrit and hemoglobin; leukocytes, neutrophils, ESR, CRP, FC, high, Presence of other heart alterations and more days of fever at the time of establishing of treatment. Risk factors for coronary involvement
Author Disclosures: P.A. Melonari: None. L.H. Llano Lopez: None. M. Olguín: None. A. Albano: None. A. Gajo Gané: None. L. Bellone: None. A. Aletti: None. A. Ellis: None. M. Calvari: None. A. Cancellara: None. N. de Carli: None. C. Euliarte: None. V. Bonardo: None. M. Leonardo: None. G. Alejandra: None. B. Mariana: None. S. Alejandro: None. T. Ivana: None. J. Petricca: None. L. Gustavo: None. F. Luis: None. A. Collia: None. V. Iris: None. B. Cristina: None. M.T. Apaz: None. R. Cutica: None. H.J. Abate: None. P.A. Melonari: None.
- © 2015 by American Heart Association, Inc.