Abstract P394: Opioid Use and Atrial Fibrillation: The Reasons for Geographic and Racial Differences in Stroke (regards) Study
Background: The use of opioids has been linked to adverse cardiovascular outcomes, suggesting a potential for an association with atrial fibrillation (AF). Conversely, opioid agonists have shown to reduce AF development in animals. It is unknown whether the use of opioids is associated with AF.
Objective: The aim of this study was to examine the baseline association between prescription opioid use and AF in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.
Methods: A total of 24,632 participants (mean age: 65 ± 9.4 years; 54% women; 40% blacks) were included in this analysis. Prescription use of opioids was ascertained by pill bottle review during the in-home study visit. AF was identified at baseline by the study electrocardiogram or self-reported history of a previous physician diagnosis. Logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) for the cross-sectional association between opioid use and AF.
Results: A total of 1,887 (7.6%) participants reported opioid use and 2,086 (8.5%) had evidence of AF at baseline. A total of 235 (12.5%) opioid users and 1,851 (8.1%) non-opioid users had AF (p<0.001). In a model adjusted for age, sex, race, region of residence, income, and education, systolic blood pressure, high density lipoprotein cholesterol, total cholesterol, body mass index, smoking, diabetes, antihypertensive and lipid-lowering medications, aspirin, coronary heart disease, stroke, C-reactive protein, serum creatinine, albumin-to-creatinine ratio, peripheral arterial disease, and electrocardiographic left ventricular hypertrophy, opioid use was associated a higher prevalence of AF (OR=1.35, 95% CI=1.16, 1.57). The results were consistent across subgroups of stratified by age, sex, race, coronary heart disease, hypertension, and diabetes.
Conclusions: In REGARDS, AF was more common among opioid users. Further research is needed to confirm our findings and to explore the underlying mechanisms of this association.
Author Disclosures: W. Qureshi: None. W. O'neal: None. M. Safford: None. P. Munter: None. Y. Khednova: None. S. Judd: None. V. Howard: None. G. Howard: None. E. Soliman: None.
- © 2015 by American Heart Association, Inc.