Abstract P381: Overlap of Echocardiographic Diastolic Dysfunction Definitions in the Cardia Study
Background: Existing echocardiographic criteria for diastolic dysfunction differ widely. We examined overlap in definitions proposed by the American Society of Echocardiography (ASE), Rochester County Epidemiology Project (Redfield), and the VALIDD trial of diastolic dysfunction among middle-aged individuals undergoing echocardiographic examination in CARDIA.
Methods: 3474 CARDIA participants had echocardiographic data at Y25. At each center, trained echo techs obtained images by a standardized protocol and scans were read centrally. Standard 2D and M-mode assessments were obtained. Published binary definitions of diastolic dysfunction were applied; pulmonary venous flow and mitral inflow at peak Valsalva maneuver measures were not available in CARDIA, so the (modified) Redfield definition of diastolic dysfunction was based on two of the four variables included in the definition.
Results: The mean age in the sample was 50.2 years, mean BMI was 30.2 kg/m2, 46.7% of the sample was African American and 53.3% was white. The prevalence of diastolic dysfunction according to different definitions was as follows: 1.6 % according to the ASE definition, 24.3% according to the VALIDD definition, and 22.4% according to the Redfield definition. Using the ASE definition, 38.9% of individuals were unclassifiable for diastolic dysfunction and using the Redfield 38.2% were unclassifiable. Overlap of the diastolic dysfunction case definitions is presented in the Figure. 51 of the 53 cases of diastolic dysfunction identified by the ASE criteria were also identified by the VALIDD criteria. Less than 50% of the cases identified by the Redfield or VALIDD criteria were classified similarly by both definitions. Although over 1317 people were unclassifiable by the ASE definition and 1326 were unclassifiable by the Redfield definition, only 348 were unclassifiable by both definitions.
Discussion: Existing definitions for diastolic dysfunction have little overlap, both for case definition and for those that are undefined.
Author Disclosures: L. Rasmussen-Torvik: None. L. Colangelo: None. J. Lima: None. D. Jacobs: None. C. Rodriguez: None. D. Lloyd-Jones: None. S. Shah: None.
- © 2015 by American Heart Association, Inc.